TITLE: “Comprehensive study of gene expression outliers and their regulation mechanisms in pan-cancer.”
ABSTRACT: Cancer is a disease characterized by remarkable heterogeneity. Gene expression varies drastically between tumours and within cells of a single. This variability can generate extreme outliers: transcripts that show atypically high gene expression in a small percentage of cancers. These outliers increase the molecular and phenotypic diversity between individuals, contributing to tumour heterogeneity. However, the previous research has been limited to a single cancer type or a single gene. To fill the gap of our understanding, this study will identify the outliers from various cancer types using our novel statistical method and explore the biological functions of outliers. With integrated analysis with the clinical outcome, it will show how outliers affect the progression of cancer. This study is expected to deepen our understanding of the impact of outliers on different cancers by dissecting their dysregulation and will allow us to identify a novel cancer driver and potential drug target.