TITLE:“Longitudinal phenotyping of Severe Mental Illness from Electronic Health Records.”
ABSTRACT:Electronic Health Records (EHRs) offer an exciting avenue for large-scale genetic studies of psychiatric disorders in globally diverse populations. As a potential source of inexpensive and longitudinal phenotypes, they are key for the study of severe mental illness trajectories. The Clinica San Juan de Dios is the only psychiatric hospital in Caldas, Colombia, serving a population of 1M people. We leverage their 15+ years of EHRs in order to 1) validate diagnoses of severe mental illness, 2) extract trans-diagnostic symptom information from free text using clinical NLP, and 3) explore patterns of temporal phenotypic variation. In addition to providing insights into the trajectory of psychiatric diagnoses, this dataset serves as a valuable resource for genetic investigation of mental illness in admixed populations.