TITLE: “Predicting Biological Aging from Epigenetics.”
ABSTRACT: Epigenetics are a proven measure of cellular health. Therefore, a field of research has emerged that utilizes epigenetics to measure, treat, and potentially reverse biological age in humans. Specifically, DNA methylation, responsible for cell differentiation and gene expression, has the potential to be a barcode for measuring biological age. Current DNA methylation aging tests require blood and are trained to predict chronological aging. To address this, we are developing a buccal swab DNA methylation test that measures fitness and general health. We utilize targeted bisulfite sequencing and are testing several machine learning techniques to generate a reliable test.
