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DTSTART;TZID=America/Los_Angeles:20240605T110000
DTEND;TZID=America/Los_Angeles:20240605T113000
DTSTAMP:20260617T005218
CREATED:20240503T141502Z
LAST-MODIFIED:20240516T230749Z
UID:26596-1717585200-1717587000@qcb.ucla.edu
SUMMARY:Research-in-Progress (RIP) Seminar: Jonathan Mah (Garud-Lohmueller)\, Graduate Student in Bioinformatics Interdepartmental Program
DESCRIPTION:TITLE: “Inference of the demographic histories and selective effects of human gut commensal microbiota over the course of human history” \nABSTRACT: Despite the importance of gut commensal microbiota to human health\, there is little knowledge about their evolutionary histories\, including their demographic histories and distributions of fitness effects (DFE) of mutations. Here\, we infer the demographic histories and DFEs for amino-acid changing mutations of 27 of the most prevalent and abundant commensal gut microbial species in North Americans over timescales exceeding human generations. We find reductions in genetic variation in North American versus African rural microbiomes. Additionally\, some species in North American microbiomes display contractions in population size and others expansions\, potentially occurring at several key historical moments in human history. DFEs across species vary from highly to mildly deleterious\, with accessory genes experiencing more drift compared to core genes. Within genera\, DFEs tend to be more congruent\, reflective of underlying phylogenetic relationships. Together\, these findings suggest that gut microbes have distinct evolutionary histories\, possibly reflecting their unique roles.
URL:https://qcb.ucla.edu/event/research-in-progress-rip-seminar-jonathan-mah-garud-lohmueller-graduate-student-in-bioinformatics-interdepartmental-program/
LOCATION:Boyer Hall 159
CATEGORIES:QCBio Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2024/05/IMG_7439.jpeg
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DTSTART;TZID=America/Los_Angeles:20240605T113000
DTEND;TZID=America/Los_Angeles:20240605T120000
DTSTAMP:20260617T005218
CREATED:20240503T141046Z
LAST-MODIFIED:20240516T230852Z
UID:26591-1717587000-1717588800@qcb.ucla.edu
SUMMARY:Research-in-Progress (RIP) Seminar: Raag Agrawal (Boutros)\, Graduate Student in Genetics & Genomics\, UCLA/Caltech MSTP
DESCRIPTION:TITLE: “Discovering biomarkers for predicting response to neo-adjuvant ADT and radionuclide treatment in high-risk prostate cancer” \nABSTRACT: Prostate cancer is the number one cause of cancer death in non-smoking American men. Next generation treatments for prostate cancer include androgen deprivation therapy (ADT) drugs such as Enzalutamide and radionuclide treatments like Lu-PSMA-617. While both of these treatment approaches are initially effective\, prostate cancer almost always recurs. We use multimodal genomic data to discover clinically useful prostate cancer subtypes to determine mechanisms of treatment resistance.  We further explore how these subtypes relate to the dearth of model systems in prostate cancer research – and whether we are ignoring clinically relevant genetic diversity in our drug development pipeline.
URL:https://qcb.ucla.edu/event/research-in-progress-rip-seminar-raag-agrawal-boutros-graduate-student-in-genetics-genomics-ucla-caltech-mstp/
LOCATION:Boyer Hall 159
CATEGORIES:QCBio Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2024/05/KGD3939.jpg
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