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DTSTART;TZID=America/Los_Angeles:20210604T110000
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DTSTAMP:20260518T022828
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SUMMARY:QCBio Research Seminar: Amelia Palermo (Graeber)
DESCRIPTION:TITLE: “Metabolic dependencies of ecDNA and HSR focal amplification modes and plasticity.” \nABSTRACT: The focal amplification (FA) of genes that support the uncontrolled growth and proliferation of cells (i.e.\, oncogenes) on homogeneous chromosomal staining regions (HSRs\, chromosomal) ans extrachromosomal DNA (ecDNA) is a hallmark of resistant cancers. However\, it remains an open question whether oncogene FA is affected by cellular metabolism and by the composition of the tumor microenvironment. This is important because cancers carrying oncogene focal amplifications\, particularly on ecDNA\, can evolve fast\, and are highly malignant and difficult to treat. In this context\, our group recently observed high plasticity of ecDNA+/HSR+ BRAF amplification upon combined BRAF plus MEK inhibitor (i.e.\, vemurafenib plus selumetinib) escalation in an in-house model of resistant melanoma. We profiled this in vitro model by metabolomics and lipidomics analysis\, revealing that both FA- vs FA+\, and ecDNA+ vs HSR+ cells are characterized by extensive metabolism reprogramming and substantial changes in lipid composition. Ultimately\, our observations support the hypothesis that oncogene focal amplification on ecDNA and HSRs can be modulated by leveraging unique metabolic vulnerabilities.
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-amelia-palermo-graeber/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/png:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/03/Amelia-Palermo.png
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DTSTART;TZID=America/Los_Angeles:20210604T113000
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DTSTAMP:20260518T022828
CREATED:20210528T004803Z
LAST-MODIFIED:20210604T195111Z
UID:18220-1622806200-1622808000@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Nan (Miles) Xi (Li JJ)
DESCRIPTION:TITLE: “DoubletCollection: An R package that integrates cutting-edge computational doublet-detection methods.”\nABSTRACT: The existence of doublets is a key confounder in single-cell RNA sequencing (scRNA-seq) data analysis. There are several computational methods for detecting doublets from scRNA-seq data.\nWe develop an R package DoubletCollection to integrate the installation and execution of those methods. DoubletCollection also provides a unified interface to perform and visualize downstream analysis after doublet detection.\nIn this talk\, we will introduce a protocol of using DoubletCollection to benchmark doublet-detection methods. This protocol can automatically accommodate new doublet-detection methods and datasets in the fast-growing scRNA-seq field.\n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/05/Nan-Miles-Xi-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-nan-miles-xi-li-jj-2/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/05/Nan-Miles-Xi.jpg
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