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X-ORIGINAL-URL:https://qcb.ucla.edu
X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211101T110000
DTEND;TZID=America/Los_Angeles:20211101T120000
DTSTAMP:20260518T005142
CREATED:20210916T153500Z
LAST-MODIFIED:20210916T155008Z
UID:18839-1635764400-1635768000@qcb.ucla.edu
SUMMARY:Bioinformatics/Human Genetics Seminar Series: Anya Prince\, Associate Professor of Law\, Genetic Cluster\, University of Iowa College of Law
DESCRIPTION:“Regulating Insurer Use of Genetic Information” \nHosted by Christina Palmer
URL:https://qcb.ucla.edu/event/bioinformatics-human-genetics-seminar-series-anya-prince-jd-associate-professor-of-law-genetic-cluster-university-of-iowa-college-of-law/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/09/Prince.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211103T120000
DTEND;TZID=America/Los_Angeles:20211103T123000
DTSTAMP:20260518T005142
CREATED:20211019T215840Z
LAST-MODIFIED:20211020T213535Z
UID:19723-1635940800-1635942600@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Alexander Markowitz (Boutros)\, Postdoc in Human Genetics
DESCRIPTION:TITLE: “A pan-cancer multi-omic analysis of tumor proliferation.” \nABSTRACT: The underlying mechanisms of dysregulated cellular proliferation in cancer remain unclear; however\, it is hypothesized that specific mutations\, mutational signatures\, evolutionary trajectories and other global (epi)genomic features may be linked to differing rates of proliferation. In this presentation\, I will showcase a landscape analysis of cellular proliferation across primary cancers and cell lines using genome\, transcriptome and proteome data from 11\,597 primary tumors and 1\,804 cell lines across six major consortia.  The approach is to develop computational pipelines that will take in next-generation sequenced\, multi-omic datasets from an expanding source of consortia\, apply rigorous statistical methods to test multiple hypotheses on the global\, functional and pharmacogenomics of tumor proliferation and output detailed integration analyses on the underlying genomics of tumor proliferation.  By evaluating proliferation at these molecular levels\, key insights will be yielded including expansive new resources on the variation of proliferation rate across and within cancer types. \nFor lunch at 12:30pm with the speaker\, please RSVP at qcboffice@lifesci.ucla.edu
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-alexander-markowitz-boutros-postdoc-in-human-genetics/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/10/IMG_0679.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211103T130000
DTEND;TZID=America/Los_Angeles:20211103T133000
DTSTAMP:20260518T005142
CREATED:20211020T212859Z
LAST-MODIFIED:20211105T032035Z
UID:19760-1635944400-1635946200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Ricky Wolff (Garud)\, Graduate Student in Ecology & Evolutionary Biology
DESCRIPTION:TITLE: “Ecological Stability Emerges at the Level of Strains in the Human Gut Microbiome.” \nABSTRACT: The human gut microbiome is a complex community that harbors substantial ecological diversity at the species level\, as well as at the strain level within species. In healthy hosts\, species abundance fluctuations in the microbiome community are thought to be stable\, and these fluctuations can be described by macroecological laws. However\, it is less clear how strain abundances change over time. An open question is whether individual strains behave like species themselves\, exhibiting stability and following the macroecological relationships known to hold at the species level\, or whether strains have different dynamics\, perhaps due to the relatively close phylogenetic relatedness of co-colonizing lineages. In this study\, we sought to characterize the typical strain-level dynamics of the healthy human gut microbiome on timescales ranging from days to years. We show that genetic diversity within almost all species is stationary\, tending towards a long-term typical value within hosts over time scales of several years\, despite fluctuations on shorter timescales. Moreover\, the abundance fluctuations of strains can be sufficiently described by a stochastic logistic model (SLM) – a model used to describe abundance fluctuations among species around a fixed carrying capacity – in the vast majority of cases\, suggesting that strains are dynamically stable. Lastly\, we find that strain abundances follow the same macroecological laws known to hold at the species level. Together\, our results suggest that macroecological properties of the human gut microbiome\, including its stability\, emerge at the level of strains. \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/10/Ricky-Wolff.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-ricky-wolff-garud-graduate-student-in-ecology-evolutionary-biology/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/10/Ricky-Wolff.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211108T110000
DTEND;TZID=America/Los_Angeles:20211108T120000
DTSTAMP:20260518T005142
CREATED:20210916T153730Z
LAST-MODIFIED:20210916T154942Z
UID:18843-1636369200-1636372800@qcb.ucla.edu
SUMMARY:Bioinformatics/Human Genetics Seminar Series: Eimear Kenny\, Founding Director\, Institute for Genomic Health\, Mount Sinai School of Medicine
DESCRIPTION:“Population genetics in an era of genomic health” \nHosted by Christa Caggiano
URL:https://qcb.ucla.edu/event/bioinformatics-human-genetics-seminar-series-eimear-kenny-phd-founding-director-institute-for-genomic-health-mount-sinai-school-of-medicine/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/09/Kenny.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211110T120000
DTEND;TZID=America/Los_Angeles:20211110T123000
DTSTAMP:20260518T005142
CREATED:20211027T205511Z
LAST-MODIFIED:20211027T205554Z
UID:19913-1636545600-1636547400@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Mariana Harris Heredia (Garud)\, Grad student in Biomathematics
DESCRIPTION:TITLE: “Differences in the Signatures of Selection Between the Autosomes and the X Chromosome in Drosophila melanogaster.” \nABSTRACT: Sex chromosomes in Drosophila are found in a hemizygous state in males. Thus\, deleterious mutations may be purged more rapidly on the X chromosome than on the autosomes. This purging can result in less available standing variation that can seed adaptation on the X chromosome. Here\, we investigate how differences in the recessivity of alleles on the X chromosome versus autosomes impact the mode and tempo of adaptation. Specifically\, we test the hypothesis that hard sweeps\, in which a single adaptive mutation rises to high frequency\, are more common on the X chromosome\, while soft sweeps\, in which multiple haplotypes rise to high frequency simultaneously\, are more common on the autosomes. We analyze D. melanogaster genomic data from two populations\, North Carolina\, and Zambia\, and find evidence that suggests that indeed\, hard sweeps are more prevalent on the X chromosome and soft sweeps are more common on the autosomes. \nFor lunch at 12:30pm with the speaker\, please RSVP at qcboffice@lifesci.ucla.edu
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-mariana-harris-heredia-garud-grad-student-in-biomathematics/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/10/Mariana-Harris-Heredia.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211110T130000
DTEND;TZID=America/Los_Angeles:20211110T133000
DTSTAMP:20260518T005142
CREATED:20211026T011133Z
LAST-MODIFIED:20211027T205757Z
UID:19880-1636549200-1636551000@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Guo Xiaohui (Pinter-Wollman)\, Postdoc in Ecology & Evolutionary Biology
DESCRIPTION:TITLE: “Decoding alarm signal propagation of seed-harvester ants\, Pogonomyrmex californicus.” \nABSTRACT: Alarm signal propagation through social-insect colonies provides an empirically tractable context for analyzing information flow through a natural system\, with useful insights for network dynamics in other social groups\, including human social networks. Here\, I develop a methodological approach to track alarm spread within the group of harvester ants\, Pogonomyrmex californicus. I alarmed initial 3 individuals and tracked subsequent signal transmission through the group. Because there was no actual threat\, the alarm was false\, allowing us to assess amplification and adaptive damping of collective alarm response. I trained a Random-Forest machine learning regression model to quantify alarm behavior of individual workers from multiple movement features associated with alarm behavior in this species. This approach provides reliable continuous assessments of an individual’s behavioral state at much finer temporal scales and more consistently than can be achieved visually. I combined the ML alarm state assessments with proximity data from tracking software (ABCTracker) to construct a propagation network of alarm spread. Using this system\, alarm propagation can be manipulated and assessed to ask and answer a wide range of questions on information and misinformation flow in social networks. \nFor lunch at 12:30pm with the speaker\, please RSVP at qcboffice@lifesci.ucla.edu
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-guo-xiaohui-pinter-wollman-postdoc-in-ecology-evolutionary-biology/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/png:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/10/Guo-Xiaohui.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211115T110000
DTEND;TZID=America/Los_Angeles:20211115T120000
DTSTAMP:20260518T005142
CREATED:20210916T153920Z
LAST-MODIFIED:20210916T154921Z
UID:18847-1636974000-1636977600@qcb.ucla.edu
SUMMARY:Bioinformatics/Human Genetics Seminar Series: Erick Matsen\,  Professor\, Public Health Sciences Division\, Associate Program Head of Herbold Computational Biology Program\, Fred Hutchinson Cancer Center
DESCRIPTION:“Towards Bayesian phylogenetics via systematic search and gradient ascent” \nHosted by Sriram Sankararaman
URL:https://qcb.ucla.edu/event/bioinformatics-human-genetics-seminar-series-erick-matsen-phd-professor-public-health-sciences-division-associate-program-head-of-herbold-computational-biology-program-fred-hutchinson-cancer-cent/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/09/Matsen.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211117T120000
DTEND;TZID=America/Los_Angeles:20211117T123000
DTSTAMP:20260518T005142
CREATED:20211005T013231Z
LAST-MODIFIED:20211117T223513Z
UID:19200-1637150400-1637152200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Chloe Yap (Gandal)\, Visiting Graduate Student\, University of Queensland
DESCRIPTION:TITLE: “Restricted diet drives autism gut-microbiome associations\, and other tales from the Australian Autism Biobank” \nABSTRACT: The Australian Autism Biobank (AAB) is an initiative of the Autism CRC – the first national\, cooperative research effort focused on autism across the lifespan. The AAB recruited a total of ~2\,500 autistic children\, family members\, and unrelated undiagnosed children\, and couples deep phenotypic information with multi-omic datasets (SNP genotyping\, stool metagenomics\, DNA methylation\, metabolomics\, WGS). One particularly controversial area in the field has been the potential causal contribution of the gut microbiome to autism. I will present results from one of the largest metagenomics study of the autism stool microbiome to date (n=246\, including 99 children diagnosed with autism). We propose a model whereby microbiome changes in autistic children may reflect consequences of behaviour and dietary preferences\, and we caution against undue emphasis on the microbiome having an upstream role in autism. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/10/Chloe-Yap.mp4\n 
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-chloe-yap-visiting-graduate-student-university-of-queensland/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/10/Chloe-Yap.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211117T130000
DTEND;TZID=America/Los_Angeles:20211117T133000
DTSTAMP:20260518T005142
CREATED:20210930T174023Z
LAST-MODIFIED:20211117T223438Z
UID:19185-1637154000-1637155800@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Paheli Desai-Chowdhry (Savage)\, Grad student in Biomathematics
DESCRIPTION:TITLE: “Asymmetric Branching Scale Factors as Features in Neuronal Cell-Type Classification” \nABSTRACT: Neurons are connected by complex branching processes – axons and dendrites – that process information for organisms to respond to their environment. Classifying neurons according to differences in structure or function is a fundamental piece of neuroscience. In previous work\, we constructed a biophysical theory that establishes a correspondence between neuron structure and function as mediated by principles such as time or power minimization\, using undetermined Lagrange multipliers to predict scaling ratios for axon and dendrite sizes across branching levels. Here\, we relax the assumption of symmetrical branching in the model to determine asymmetric branching powers that differ across different cell types due to functional tradeoffs. Furthermore\, we use scale factors related to asymmetric branching as features in machine learning classification to distinguish between different cell types. We find significant distinctions in the asymmetric scaling ratios between Purkinje cells and motoneurons. The performance of these classification methods gives us important insights into the correspondence between structure and function across different cell types. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/09/Paheli-Desai-Chowdhri.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-paheli-desai-chowdhry-savage-grad-student-in-biomathematics/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/09/Paheli-Desai-Chowdhry.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211122T110000
DTEND;TZID=America/Los_Angeles:20211122T120000
DTSTAMP:20260518T005142
CREATED:20210916T154109Z
LAST-MODIFIED:20210916T154109Z
UID:18851-1637578800-1637582400@qcb.ucla.edu
SUMMARY:Bioinformatics/Human Genetics Seminar Series: Katie Peichel\, Head of the Division Evolutionary Ecology\, University of Bern
DESCRIPTION:“The role of chromosome evolution in adaptation and speciation in stickleback fish” \nHosted by Kirk Lohmueller
URL:https://qcb.ucla.edu/event/bioinformatics-human-genetics-seminar-series-katie-peichel-head-of-the-division-evolutionary-ecology-university-of-bern/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/09/Peichel.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211129T110000
DTEND;TZID=America/Los_Angeles:20211129T120000
DTSTAMP:20260518T005142
CREATED:20210916T154748Z
LAST-MODIFIED:20210916T154748Z
UID:18855-1638183600-1638187200@qcb.ucla.edu
SUMMARY:Bioinformatics/Human Genetics Seminar Series: Stephen Piccolo\, Associate Professor\, Biology\, Member of Simmons Center for Cancer Research\, Brigham Young University
DESCRIPTION:TITLE: “TBD” \nHosted by Sarah Spendlove
URL:https://qcb.ucla.edu/event/bioinformatics-human-genetics-seminar-series-stephen-piccolo-associate-professor-biology-member-of-simmons-center-for-cancer-research-brigham-young-university/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/09/Piccolo.jpg
END:VEVENT
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