BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Quantitative and Computational Biosciences - ECPv6.16.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://qcb.ucla.edu
X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220701T160000
DTEND;TZID=America/Los_Angeles:20220701T170000
DTSTAMP:20260517T134644
CREATED:20220629T201042Z
LAST-MODIFIED:20220719T144054Z
UID:21819-1656691200-1656694800@qcb.ucla.edu
SUMMARY:QCBio/BIG Summer Research Seminar: Dr. Harold Pimentel\, Assistant Professor in Computational Medicine & Human Genetics\, UCLA
DESCRIPTION:TITLE: “Model driven design and analysis of functional screens” \nABSTRACT: A little over a decade ago biomedicine was revolutionized by a conceptually simple insight: DNA sequencers could be used as molecular counting machines to measure a multitude of molecules beyond DNA. Through the years\, sequencing has continued to become cheaper and more efficient (faster than Moore’s Law) and thousands of clever assays have been developed. This development has led to thousands of experiments done regularly with new data modalities arising continuously. However\, this development has also led to a number of interesting computational problems: how does one design an experiment such that reasonable power is achieved? What can actually be measured? And finally\, how does one even perform an analysis on such data once it has arrived?
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-in-collaboration-with-big-summer-dr-harold-pimentel-assistant-professor-in-computational-medicine-human-genetics-ucla/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2022/06/Harold-Pimentel.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220708T160000
DTEND;TZID=America/Los_Angeles:20220708T170000
DTSTAMP:20260517T134644
CREATED:20220629T223906Z
LAST-MODIFIED:20220719T144039Z
UID:21823-1657296000-1657299600@qcb.ucla.edu
SUMMARY:QCBio/BIG Summer Research Seminar: Dr. Nandita Garud\, Assistant Professor Assistant Professor\, Department of Ecology and Evolutionary Biology\, UCLA
DESCRIPTION:TITLE: “Evolutionary dynamics in the human gut microbiome from infancy through adulthood.” \nABSTRACT: While the ecological dynamics of the infant gut microbiome have been intensely studied\, relatively little is known about the evolutionary dynamics in the infant gut microbiome. Here we analyze longitudinal fecal metagenomic data from >700 infants and their mothers over the first year of life and find that the evolutionary dynamics in infant gut microbiomes are distinct from that of adults. We find evidence for almost 100-fold increase in the rate of evolution and strain turnover in the infant gut compared to healthy adults\, with the mother-infant transition at delivery being a particularly dynamic period in which gene loss dominates. Within a few months after birth\, these dynamics stabilize\, and gene gains become increasingly frequent as the microbiome matures. We furthermore find that evolutionary changes in infants show signatures of being seeded by a mixture of de novo mutations and transmissions of pre-evolved lineages from the broader family. Several of these evolutionary changes occur in parallel in multiple infants\, highlighting candidate genes that may play important roles in the development of the infant gut microbiome. Our results point to a picture of a volatile infant gut microbiome characterized by rapid evolutionary and ecological change in the early days of life.
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-in-collaboration-with-big-summer-dr-nandita-garud-assistant-professor-assistant-professor-department-of-ecology-and-evolutionary-biology-ucla/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2022/06/Nandita-Garud.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220715T160000
DTEND;TZID=America/Los_Angeles:20220715T170000
DTSTAMP:20260517T134644
CREATED:20220713T185015Z
LAST-MODIFIED:20220719T144022Z
UID:21881-1657900800-1657904400@qcb.ucla.edu
SUMMARY:QCBio/BIG Summer Research Seminar: Dr. Eric Deeds\, Associate Professor - Vice Chair\, Life Sciences Core\, UCLA
DESCRIPTION:TITLE: “A lack of distinct cellular identities in scRNA-seq data: revisiting Waddington’s landscape”. \nABSTRACT: Single-cell RNA sequencing is revolutionizing our understanding of development\, differentiation and disease. Analysis of this data is often challenging\, however\, and tasks like clustering cells to uncover distinct cellular identities sometimes yields results that fail to align with existing biological knowledge. We analyzed publicly available data where the cell identity for each cell is known a priori\, and found that cells of very different types and lineages do not occupy distinct regions of gene expression space. Rather\, cells from different lineages overlap extensively with one another\, significantly complicating attempts to recover distinct identities within the data. Indeed\, our analysis of available epigenetic data for a wide variety of tissues and organisms revealed these data are not consistent with the predictions of Waddington’s landscape\, suggesting a need to revisit our picture of gene expression changes during differentiation and development.
URL:https://qcb.ucla.edu/event/qcbio-big-summer-research-seminar-dr-eric-deeds-associate-professor-vice-chair-life-sciences-core-ucla/
LOCATION:Boyer Hall 159
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2022/07/ERIC-DEEDS.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220722T160000
DTEND;TZID=America/Los_Angeles:20220722T170000
DTSTAMP:20260517T134644
CREATED:20220719T143305Z
LAST-MODIFIED:20220719T143940Z
UID:21889-1658505600-1658509200@qcb.ucla.edu
SUMMARY:QCBio/BIG Summer Research Seminar: Dr. Eleazar Eskin\, Professor and Chair Department of Computational Medicine\, UCLA
DESCRIPTION:TITLE: “Swab-Seq: Detecting COVID-19 with Genomic Sequencing: From bench to vending machine.” \nABSTRACT: At UCLA we developed one of the only novel technologies for COVID-19 diagnostic testing that was deployed on a large scale.  The assay\, which we named SwabSeq\, performs genomic sequencing of pooled samples tagged with sample-specific molecular barcodes and then uses computational approaches to deconvolve the pooled samples into individual diagnoses\, enabling the testing of thousands of nasal or saliva samples for SARS-CoV-2 RNA in a single run without the need for RNA extraction.   The efficiency of SwabSeq has enabled a small facility with a handful of staff to perform over 1\,000\,000 tests\, with an analytical sensitivity and specificity comparable to or better than traditional qPCR test with turnaround times of less than 24 h. SwabSeq could be rapidly adapted for the detection of other pathogens.
URL:https://qcb.ucla.edu/event/qcbio-big-summer-research-seminar-dr-eleazar-eskin-professor-and-chair-department-of-computational-medicine-ucla/
LOCATION:529 Boyer Hall\, 611 Charles E Young Dr E\,\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2022/07/Eleazar-Eskin-400x400-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220729T160000
DTEND;TZID=America/Los_Angeles:20220729T170000
DTSTAMP:20260517T134644
CREATED:20220719T143848Z
LAST-MODIFIED:20220719T143848Z
UID:21894-1659110400-1659114000@qcb.ucla.edu
SUMMARY:QCBio/BIG Summer Research Seminar: Dr. Xia Yang\, Professor\, Dept. Integrative Biology & Physiology\, UCLA
DESCRIPTION:TITLE: “Integrative systems analysis\, applications\, and challenges of single cell multiomics.” \nABSTRACT: Recent advances in single cell multiomics technologies such as single cell RNA-seq\, single cell ATAC-seq\, and spatial transcriptomics have brought enormous opportunities that enable our understanding of the molecular underpinnings of pathophysiology at a single cell resolution. However\, integrative analysis across single cell multiomics domains and further incorporation of genetics information have proven challenging.  I will introduce our recent efforts in single cell multiomics integration\, network modeling\, and eQTL analysis\, present computational tools to carry out these analyses\, and showcase application examples in studies of traumatic brain injury\, Alzheimer’s disease\, and genetic control of cell-type specific hypothalamic cell types to regulate energy homeostasis. I will also highlight the challenges and future directions of integrative systems  analysis of single cell multiomics data.
URL:https://qcb.ucla.edu/event/qcbio-big-summer-research-seminar-dr-xia-yang-professor-dept-integrative-biology-physiology-ucla/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2022/07/Yang_Xia_Headshot-300x300-1.jpg
END:VEVENT
END:VCALENDAR