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X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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DTSTART;TZID=America/Los_Angeles:20230707T160000
DTEND;TZID=America/Los_Angeles:20230707T170000
DTSTAMP:20260516T220754
CREATED:20230627T234736Z
LAST-MODIFIED:20230627T234745Z
UID:24835-1688745600-1688749200@qcb.ucla.edu
SUMMARY:BIG Summer Research Seminar: Xia Yang\, Professor\, Integrative Biology and Physiology Molecular and Medical Pharmacology at UCLA
DESCRIPTION:TITLE: “Single Cell Multiomics Integration to Understand Complex Diseases.” \nABSTRACT: Recent advances in single cell multiomics technologies such as single cell RNA-seq\, single cell ATAC-seq\, and spatial transcriptomics have brought enormous opportunities that enable our understanding of the molecular underpinnings of pathophysiology at a single cell or cell type resolution. However\, integrative analysis across single cell multiomics domains has proven challenging.  I will introduce our recent efforts in single cell multiomics integration and gene regulatory network modeling\, present computational tools to carry out these analyses\, and showcase application examples in studies of various complex diseases. \n 
URL:https://qcb.ucla.edu/event/big-summer-research-seminar-xia-yang-professor-integrative-biology-and-physiology-molecular-and-medical-pharmacology-at-ucla/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2023/06/Xia-Yang-Ph.D..jpg
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DTSTART;TZID=America/Los_Angeles:20230714T160000
DTEND;TZID=America/Los_Angeles:20230714T170000
DTSTAMP:20260516T220754
CREATED:20230711T184053Z
LAST-MODIFIED:20230711T184148Z
UID:24861-1689350400-1689354000@qcb.ucla.edu
SUMMARY:BIG Summer Research Seminar: Xianghong Jasmine Zhou\, Professor\, Pathology and Laboratory Medicine at UCLA
DESCRIPTION:TITLE: “Liquid Biopsies for Precision Oncology.” \nABSTRACT: Liquid biopsies are new diagnostic approaches to profile molecular features of solid tumors by blood\, saliva\, urine\, and other body fluids. Such approaches offer non-invasive options in early cancer detection\, tumor sampling\, continuous monitoring\, and designing personalized therapeutic options. Therefore\, liquid biopsies have the potential to transform the field of clinical oncology. Recently\, cell-free DNA analysis from a simple blood draw received enormous attention for its promise in these applications. In this talk\, we will discuss several novel computational and experimental technologies on using cell-free DNA for the detection and monitoring of cancer and other diseases.
URL:https://qcb.ucla.edu/event/big-summer-research-seminar-xianghong-jasmine-zhou-professor-pathology-and-laboratory-medicine-at-ucla/
LOCATION:Boyer Hall 159
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2023/07/Jasmine_round-3.jpeg
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DTSTART;TZID=America/Los_Angeles:20230721T160000
DTEND;TZID=America/Los_Angeles:20230721T170000
DTSTAMP:20260516T220754
CREATED:20230719T152504Z
LAST-MODIFIED:20230719T152504Z
UID:24886-1689955200-1689958800@qcb.ucla.edu
SUMMARY:BIG Summer Research Seminar: Jimmy Hu\, Assistant Professor in the Division of Oral Biology & Medicine at the UCLA School of Dentistry
DESCRIPTION:TITLE: “Building a tooth from transcriptome to tissue morphogenesis” \nABSTRACT: During craniofacial development\, the oral epithelium begins as a morphologically homogeneous tissue that gives rise to locally complex structures\, including the teeth\, salivary glands\, and taste buds. How the epithelium is initially patterned and later shaped to generate diverse organ and cell types remains largely unknown. To elucidate the genetic programs that direct the formation of distinct oral epithelial populations\, we mapped the transcriptional landscape of embryonic day (E) 12 mouse mandibular epithelia at single cell resolution. Our analysis identified key transcription factors and gene regulatory networks that define different epithelial cell types. By examining the spatiotemporal patterning process along the oral-aboral axis\, our results inform a model where the dental field is progressively confined to its position by the formation of the aboral epithelium anteriorly and the non-dental oral epithelium posteriorly. As dental suprabasal cells are enriched with genes related to actomyosin-based motility\, we next studied mutant embryos lacking non-muscle myosin II to explore the roles of cellular forces during tooth morphogenesis. We found that myosin II is critical for maintaining cell-cell adhesion and for efficient cellular movement that drives dental epithelial invagination. Together\, our results describe the transcriptional regulation during oral epithelial patterning and unveil an actomyosin-based mechanism that promotes tooth invagination.
URL:https://qcb.ucla.edu/event/big-summer-research-seminar-jimmy-hu-assistant-professor-in-the-division-of-oral-biology-medicine-at-the-ucla-school-of-dentistry/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2023/07/Jimmy-Hu.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230724T110000
DTEND;TZID=America/Los_Angeles:20230724T120000
DTSTAMP:20260516T220754
CREATED:20230719T153531Z
LAST-MODIFIED:20230719T153531Z
UID:24891-1690196400-1690200000@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Andras Gyorgy\, Assistant Professor of Electrical Engineering and Bioengineering - NYU Abu Dhabi
DESCRIPTION:TITLE: “Inducible plasmid copy number control and a blueprint for a synthetic genetic feedback optimizer” \nABSTRACT: The ability to control gene expression has been paradigm shifting for all areas of biological research\, especially for synthetic biology. This talk will focus on two recent advancements in gene expression control. First\, TULIP (TUnable Ligand Inducible Plasmid) is presented: a self-contained plasmid with inducible copy number control\, designed for portability across various Escherichia coli strains commonly used for cloning\, protein expression\, and metabolic engineering. As demonstrated through multiple application examples\, flexible plasmid copy number control via TULIP accelerates the design and optimization of gene circuits\, enables efficient probing of metabolic burden\, and facilitates the prototyping and recycling of modules in different genetic contexts. Second\, the blueprint of a genetic feedback module is presented to optimize a broadly defined performance metric by adjusting the production and decay rate of a set of regulator species. The optimizer can be implemented by combining available synthetic biology parts and components\, and it can be readily integrated with existing pathways and genetically encoded biosensors to ensure its successful deployment in a variety of settings when relying on mass action kinetics-based dynamics and parameter values typical in Escherichia coli.
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-andras-gyorgy-assistant-professor-of-electrical-engineering-and-bioengineering-nyu-abu-dhabi/
LOCATION:Boyer Hall 130
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2023/07/Andras-Gyorgy-7.24.jpg
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