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DTSTART;TZID=America/Los_Angeles:20210113T090000
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SUMMARY:Developmental Systems Biology Faculty Search - MCDB | QCBio | BSCRC Seminar: Adrian Jacobo\, PhD\, The Rockefeller University\, New York\, NY
DESCRIPTION:TITLE: “Symmetry breaking during morphogenesis of a mechanosensory organ” \nABSTRACT: The development of mechanosensory epithelia\, such as those of the auditory and vestibular systems\, results in the precise orientation of mechanosensory hair cells and consequently directional sensitivity. After division of a precursor cell in the zebrafish lateral line\, the daughter hair cells differentiate with opposite mechanical sensitivity. This process produces neuromasts containing equal numbers of hair cells of two opposite polarities\, half of them sensitive to caudad water movement and half to rostrad flow.  \nUsing a combination of experimental tools and mathematical modeling we show how Notch-mediated lateral inhibition produces a bistable switch that reliably gives rise to hair-cell pairs of opposite polarity. This spontaneous symmetry breaking drives polarity-dependent movements of hair cells that lead to the establishment of a mirror-symmetric organization of the organ. We model these reconfigurations by describing the effective surface tensions of the hair cells and the changes in these quantities throughout the developmental process. These results provide a unified experimental and theoretical framework to describe the polarity selection and directed migration of hair cells in the zebrafish lateral line. 
URL:https://qcb.ucla.edu/event/developmental-systems-biology-faculty-search-mcdb-qcbio-bscrc-seminar-adrian-jacobo-phd-the-rockefeller-university-new-york-ny/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Seminar-flyer-Adrian-Jacobo3.jpg
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DTSTART;TZID=America/Los_Angeles:20210113T110000
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DTSTAMP:20260518T105411
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LAST-MODIFIED:20210114T192851Z
UID:15901-1610535600-1610539200@qcb.ucla.edu
SUMMARY:Developmental Systems Biology Faculty Search - MCDB | QCBio | BSCRC Seminar: Eviatar Yemini\, PhD\, Columbia University\, New York\, NY
DESCRIPTION:TITLE: “Biologist\, Know Thy Cells – A Colorful Barcoding Method to ID Cell Types\, their Fate\, and Decode Brainwide Communication” \nABSTRACT: A major challenge in biological imaging is resolving cell identities. These are necessary for determining cell-specific protein expression and function\, the effect of transcription factors on cell fate\, and the contribution of individual neurons to brainwide activity and behavior. Present methods are limited to a piecemeal approach\, using multiple strains to identify a few cell types at a time. I introduce a new method and software that can identify many cell types\, and in some cases all neurons\, in vivo using a single strain. My method combines cell reporters with five distinguishable fluorescent proteins to create unique\, stereotyped color codes that identify cell types. I illustrate this in C. elegans\, engineering a multicolor transgene called NeuroPAL (a Neuronal Polychromatic Atlas of Landmarks)\, to create an identical colormap in all worms that uniquely identifies every neuron\, showcasing three applications. First\, I identify the neuronal expression patterns of all metabotropic receptors for acetylcholine\, GABA\, and glutamate\, thus completing a map of this communication network. My findings indicate that second-messenger systems are the primary means of GABA communication in worm\, and further suggest widespread extrasynaptic GABA signaling. Second\, I analyze the conserved transcription factor EOR-1/PLZF and\, despite its ubiquitous expression\, uncover a precise role in neuronal fate. Third\, I identify brainwide codes for gustatory and olfactory stimuli. My findings show a complex code that challenges the present view that global neuronal activity is simply low dimensional. To facilitate the workflow\, I present semi-automated cell identification software and optimal-coloring software to apply the same method in other tissues and organisms. Lastly\, I discuss future applications: investigating how whole-nervous-system activity is remodeled to change behavior during early development\, sexual maturation\, in response to environmental stress\, and even across 15+ million years of evolutionary divergence. 
URL:https://qcb.ucla.edu/event/developmental-systems-biology-faculty-search-mcdb-qcbio-bscrc-seminar-eviatar-yemini-phd-columbia-university-new-york-ny/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
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