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X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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DTSTART;TZID=America/Los_Angeles:20210115T110000
DTEND;TZID=America/Los_Angeles:20210115T233000
DTSTAMP:20260518T110128
CREATED:20210109T154453Z
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SUMMARY:QCBio Research Seminar: Sharmila Venugopal (Part II)
DESCRIPTION:TITLE: “Merging Experimental and Computational Approaches to Study Neurodegenerative Disease Dynamics” \nABSTRACT: “Neurodegenerative diseases such as Alzheimer’s and Parkinson’s affect millions of people around the world and are a growing health concern in aging populations. A major roadblock in developing effective treatments involve the diverse etiology and progression rates\, combined with a lack of clear understanding of how disease alters the nervous system. Basic science plays a crucial role in developing a deeper understanding of pre-symptomatic disease mechanisms using animal models of human disease.  Exploiting this opportunity\, our lab has taken a unique stride to merge data-driven computational modeling with diverse experimental approaches to examine the workings of a neural microcircuit and its vulnerability in neurodegeneration. In my talk\, I will discuss our work on computational and mathematical modeling \, use of a biohybrid technique to integrate models into experiments in real-time\, and our novel findings in a devastating neurodegenerative motor neuron disease\, Amyotrophic Lateral Sclerosis\, commonly known as Lou Gehrig’s disease.” \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/01/Sharmila-Venugopal-edited-1.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-sharmila-venugopal-part-ii/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Sharmila-Venugopal.jpg
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DTSTART;TZID=America/Los_Angeles:20210115T113000
DTEND;TZID=America/Los_Angeles:20210115T120000
DTSTAMP:20260518T110128
CREATED:20210103T195622Z
LAST-MODIFIED:20210115T220924Z
UID:15384-1610710200-1610712000@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Cyrillus Tan (Meyer)
DESCRIPTION:TITLE: “A quantitative view of strategies to engineer cell-selective ligand binding” \nABSTRACT: Selective binding to specific target cells is a critical property of many therapies. To enhance selectivity in specific situations\, a series of new strategies have been proposed in the drug development literature\, including affinity\, valency\, multi-specificity\, and other alterations to target cell binding. We have developed a simple and general\, multivalent ligand-receptor binding model that can help to direct therapeutic engineering. Using this model\, we provide generalized and quantitative analyses of the effectiveness and limitations of each strategy. We also demonstrate that combining strategies can offer enhanced selectivity. This work provides guidance for future therapeutic development. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/01/Cyrillus-Tan-edited.mp4
URL:https://qcb.ucla.edu/event/research-seminar-cyrillus-tan-meyer/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Cyrillus-Tan.jpeg
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DTSTART;TZID=America/Los_Angeles:20210115T120000
DTEND;TZID=America/Los_Angeles:20210115T130000
DTSTAMP:20260518T110128
CREATED:20210114T193131Z
LAST-MODIFIED:20210114T193131Z
UID:15905-1610712000-1610715600@qcb.ucla.edu
SUMMARY:Developmental Systems Biology Faculty Search - MCDB | QCBio | BSCRC Seminar: Juan Alvarez\, PhD\, Harvard University\, Cambridge\, MA
DESCRIPTION:TITLE: “Organoid Maturation by Circadian Entrainment “ \nABSTRACT: Stem cell-derived tissues that recap endogenous physiology are key for regenerative medicine. Yet\, most methods yield products that function like fetal\, not adult tissues. Organoids are typically grown in constant environments\, while our tissues mature along with behavioral cycles. I show that inducing circadian rhythms in pancreatic islet organoids\, by entraining them to daily feeding-fasting cycles or “meals”\, elicits their metabolic maturation. The results show that rhythms can be harnessed to further functional maturation of organoids destined for human therapeutics. 
URL:https://qcb.ucla.edu/event/developmental-systems-biology-faculty-search-mcdb-qcbio-bscrc-seminar-juan-alvarez-phd-harvard-university-cambridge-ma/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Seminar-flyer-Juan-Alvarez3.jpg
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