BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Quantitative and Computational Biosciences - ECPv6.16.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://qcb.ucla.edu
X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20200308T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20201101T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210120T110000
DTEND;TZID=America/Los_Angeles:20210120T120000
DTSTAMP:20260518T105427
CREATED:20210114T191248Z
LAST-MODIFIED:20210114T194013Z
UID:15883-1611140400-1611144000@qcb.ucla.edu
SUMMARY:Developmental Systems Biology Faculty Search - MCDB | QCBio | BSCRC Seminar: Yogesh Goyal\, PhD\, University of Pennsylvania\, Philadelphia\, PA
DESCRIPTION:TITLE: “Cellular plasticity and fate choices in developing tissues and single cancer cells” \nABSTRACT: While cellular processes are often reproducible and precise\, cells may also alter their molecular states and adopt new fates in response to stimuli\, a phenomena referred to as “plasticity”. I am interested in understanding the control principles governing cellular plasticity and fate decisions in response to mutational and pharmacologic stresses in tissue development and cancer. I will first describe my work on quantitative approaches to monitor and control developmental signaling during fly embryogenesis. My findings reveal the complex and counterintuitive effects of pathogenic germline mutations in the highly conserved Ras signaling pathway on spatiotemporal patterning and morphogenesis. This work has implications for a large class of developmental abnormalities and our understanding of their origins and potential treatments. The second part of my talk is motivated by recent studies revealing how rare and transient non-genetic fluctuations in individual cancer cells enable them to survive pharmacologic stress\, such as molecularly targeted therapies. Unlike the binary nature of Darwinian selection whereby mutations are either present or not\, non-genetic fluctuations can exist on one\, or even multiple continuums of variation. How this non-genetic variability maps to the eventual resistant fates upon drug exposure is an emerging paradigm of cellular plasticity. Integrating novel theoretical and experimental frameworks\, I will present my findings on 1. Identifying the origins and nature of the unique transcriptional molecular states underlying this plasticity; and 2. Connecting these molecular states to their eventual drug-resistant fates by tracking thousands of uniquely barcoded cell lineages. Moving forward\, my group will adapt these quantitative approaches and concepts to measure\, model\, and engineer plasticity and its roles in tissue development and disease. 
URL:https://qcb.ucla.edu/event/developmental-systems-biology-faculty-search-mcdb-qcbio-bscrc-seminar-yogesh-goyal-p-h-d-university-of-pennsylvania-philadelphia-pa/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Seminar-flyer-Yogesh-Goyal2.jpg
END:VEVENT
END:VCALENDAR