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SUMMARY:Developmental Systems Biology Faculty Search - MCDB | QCBio | BSCRC Seminar: Michael F. Wells\, PhD\, Broad Institute & Harvard University\, Cambridge\, MA
DESCRIPTION:TITLE: “Exploration of human genetic and phenotypic diversity through cell villages” \nABSTRACT: Our species is characterized by an immense diversity in neurological and psychological traits. Common and rare genetic variants have been linked to trait differences and disease risk in human populations\, though the underlying biology is poorly understood and difficult to study at large scales. In this presentation\, I will first describe a novel experimental platform that enables high-throughput investigations into the influence of human genetic variation on the earliest stages of brain development. This system\, known as a “cell village” captures genetic\, molecular\, and phenotypic heterogeneity in a shared in vitro environment\, thus facilitating the detection of relationships among human alleles\, gene expression\, and cellular behaviors. I will then describe how I used cell villages to identify a single nucleotide polymorphism in the IFITM3 gene that could explain over half of the variance in neural progenitor cell susceptibility to the Zika virus\, which is a pathogen that causes severe neurodevelopmental disorders. I will conclude with a brief discussion on the future of the village approach and how I plan to deploy this technology to investigate the role of progenitor cell competition in neurodevelopment and disease. 
URL:https://qcb.ucla.edu/event/developmental-systems-biology-faculty-search-mcdb-qcbio-bscrc-seminar-speaker-michael-f-wells-phd/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Seminar-flyer-Michael-Wells1.jpg
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DTSTART;TZID=America/Los_Angeles:20210121T130000
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UID:15913-1611234000-1611237600@qcb.ucla.edu
SUMMARY:Developmental Systems Biology Faculty Search - MCDB | QCBio | BSCRC Seminar: Amjad Askary\, PhD\, California Institute of Technology\, Pasadena\, CA
DESCRIPTION:TITLE: “Imaging-based genetic recording of developmental histories” \nABSTRACT: Systems-level understanding of cell fate decisions has been hampered by limitations of the existing methods to capture developmental history of the cells. Synthetic recording\, which uses genome editing to create sequence diversity in genetic barcodes\, is emerging as a promising approach for mapping cell lineage and molecular history. However\, readout of the information stored in the barcodes by sequencing leads to loss of crucial information about the spatial context of the cells and their organization in the tissue. We have developed a system for scalable in situ readout of DNA barcodes and single nucleotide modifications in cells and tissue sections. Together with multiplexed in situ transcriptional profiling and CRISPR base editing\, this method enables us to trace lineage of many cells in each individual embryo\, reconstruct lineage trees\, and even connect the gene expression and signaling history of the progenitors to their eventual fates. In this talk\, I present our approach to imaging-based barcoding and discuss how this technology can be used to investigate elusive aspects of cell fate specification in the mammalian retina.  \n 
URL:https://qcb.ucla.edu/event/developmental-systems-biology-faculty-search-mcdb-qcbio-bscrc-seminar-amjad-askary-phd-california-institute-of-technology-pasadena-ca/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Seminar-flyer-Amjad-Askary-1.jpg
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