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X-WR-CALNAME:Institute for Quantitative and Computational Biosciences
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X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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DTSTART;TZID=America/Los_Angeles:20210122T110000
DTEND;TZID=America/Los_Angeles:20210122T113000
DTSTAMP:20260518T105412
CREATED:20210112T232941Z
LAST-MODIFIED:20210114T014126Z
UID:15806-1611313200-1611315000@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Tevfik Umut Dincer (Ernst)
DESCRIPTION:TITLE: “Genomewide supervised prediction of activating and repressive regions in over hundred cell and tissue types” \nABSTRACT: While the vast majority of variants associated with common disease risk are distributed across the non-coding genome\, our understanding of the regulatory elements contained within remains notably incomplete. Strategies for identifying and characterizing these regulatory elements\, such as high-throughput reporter assays and CRISPR-dCas9 screens\, have been essential in decoding this complex regulatory landscape\, but they only provide information on the particular regions they cover and are currently available only in a limited number of cell types. By leveraging data from these functional assays and epigenetic features (such as histone modifications and chromatin accessibility)\, we built a supervised model to estimate the activating and repressive potential of any particular segment of the genome for over hundred cell and tissue types. We evaluate how our model learns regulatory activity from different datasets and investigate strategies for generalizing regulatory activity predictions to multiple cell types.
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-tevfik-dincer-ernst/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/tevfik_dincer_photo_800.jpg
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DTSTART;TZID=America/Los_Angeles:20210122T113000
DTEND;TZID=America/Los_Angeles:20210122T120000
DTSTAMP:20260518T105412
CREATED:20210104T174455Z
LAST-MODIFIED:20210104T174725Z
UID:15463-1611315000-1611316800@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Iris Dror (Plath)
DESCRIPTION:TITLE: “XIST controls X chromosome dampening and autosomal genes in early human development” \nABSTRACT: \nFemale human pre-implantation embryos and naïve human pluripotent stem cells (hPSCs) equalize X-linked gene expression with males via X-chromosome dampening (XCD)\, a unique strategy of dosage compensation in mammals. The mechanisms controlling XCD are unknown. Here\, we show that the long non-coding RNA XIST\, which mediates X-chromosome inactivation (XCI)\, is required for XCD. XIST employs similar principles and protein partners\, including SPEN\, to execute XCD and XCI\, but displays a lower accumulation and different distribution on the dampened versus the inactive X. Unexpectedly\, XIST also spreads to specific autosomal regions and induces the downregulation of autosomal developmental genes in female naïve hPSCs and pre-implantation embryos. Thus\, XIST balances X-linked gene expression but causes imbalances in autosomal gene expression between male and female cells in early human development. Together\, our results show that the XIST-SPEN-axis can induce distinct gene expression outputs on the X-chromosome and transiently regulate autosomal genes in humans.
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-iris-dror-plath/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Iris-Dror.jpg
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