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X-WR-CALNAME:Institute for Quantitative and Computational Biosciences
X-ORIGINAL-URL:https://qcb.ucla.edu
X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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DTSTART;TZID=America/Los_Angeles:20210205T110000
DTEND;TZID=America/Los_Angeles:20210205T120000
DTSTAMP:20260518T065737
CREATED:20210107T162654Z
LAST-MODIFIED:20210205T203344Z
UID:15717-1612522800-1612526400@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Lingyun (Ivy) Xiong (Garfinkel)
DESCRIPTION:TITLE: “Oncogenic alterations in the p53 pathway abolish oscillatory competence” \nABSTRACT: The tumor suppressor p53 displays concentration oscillations in response to DNA damage\, a behavior that has been suggested to be essential to its anti-cancer function.  Many genetic alterations in the p53 pathway have been shown to be oncogenic\, whether by experiment or by clinical associations with various cancers. These oncogenic alterations include somatic mutations\, copy number variations and inherited polymorphisms. Using a differential equation model of p53-Mdm2 dynamics\, we employ Hopf bifurcation analysis to show that all of the oncogenic perturbations have a common effect\, to abolish the oscillatory competence of p53\, thereby impairing its tumor suppressor function. In this analysis\, these diverse genetic alterations\, widely observed in human cancers\, have a unified mechanistic explanation. \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/01/Ivy-Xiong-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-lingyun-ivy-xiong-garfinkel/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/png:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Lingyun-Ivy-Xiong.png
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DTSTART;TZID=America/Los_Angeles:20210205T113000
DTEND;TZID=America/Los_Angeles:20210205T120000
DTSTAMP:20260518T065737
CREATED:20210129T140921Z
LAST-MODIFIED:20210226T201021Z
UID:16320-1612524600-1612526400@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Marcus Gallagher-Jones (Rodriguez)
DESCRIPTION:TITLE: Structural interrogation of small open reading frame (sORF) encoded proteins \nABSTRACT: Advances in genomics and proteomics have unearthed sequences of a startling number of novel proteins. Despite this\, our knowledge of their three-dimensional structure and function relies on only a small fraction of the known protein universe.  Small open reading frames (sORFs) encoding proteins less than 100 amino acids in length are an extreme example of this. With tens of thousands of newly discovered sORFs per year since the late 2000s\, their gene products represent a kind of ‘dark matter’ of the proteome. Many sORF families encode sequences that do not resemble a known protein domain\, limiting our ability to correlate their sequence to a known function. Given the widespread roles previously characterized small proteins play in bacterial cells\, they hold great potential as future therapeutic targets. My current research is focussed on leveraging advances in protein structure prediction to discover sORF encoded proteins (SEP) with a compact tertiary structure and tease out the role they may be playing in cellular function. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/01/Marcus-Gallagher-Jones-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminars-marcus-gallagher-jones-sankararaman/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Marcus-Gallagher-Jones.jpg
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DTSTART;TZID=America/Los_Angeles:20210205T120000
DTEND;TZID=America/Los_Angeles:20210205T130000
DTSTAMP:20260518T065737
CREATED:20210203T154838Z
LAST-MODIFIED:20210203T154841Z
UID:16436-1612526400-1612530000@qcb.ucla.edu
SUMMARY:COVID-19 Basic\, Translational and Clinical Research Seminar Series
DESCRIPTION:Swab-Seq: Massively scaling SARS-CoV-2 testing using genomic sequencing. \nThe COVID-19 Basic\, Translational and Clinical Research Task Forces has created a seminar series each Friday at noon. The purpose of these seminars is to bring together people across campus working on SARS-CoV-2 from all angles to form a community and exchange information\, both for expert virologists and those new to COVID-19 from other disciplines. Some presentations will focus on individual COVID-19 research projects and others on discussion of tools and reagents and campus resources. We hope this will also be a venue to identify collaborations for larger projects and grant opportunities. \nPlease note zoom below requires pre-registration: \nhttps://uclahs.zoom.us/meeting/register/tJIsd-mpqDkuHNFCfaOEkKnLO0lALIGPQGpW \nAfter registering\, you will receive a confirmation email containing information about joining the meeting.
URL:https://qcb.ucla.edu/event/covid-19-basic-translational-and-clinical-research-seminar-series/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
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