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X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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DTSTART;TZID=America/Los_Angeles:20210219T110000
DTEND;TZID=America/Los_Angeles:20210219T113000
DTSTAMP:20260518T075340
CREATED:20210112T233728Z
LAST-MODIFIED:20210222T201152Z
UID:15821-1613732400-1613734200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Igor Nikolskiy (Wollman)
DESCRIPTION:TITLE: “A state space model to characterize the phenotypic variation in a panel of drug treatment time course experiments.” \nABSTRACT: As new technologies enable high throughput collection of marker measurements in drug treatment time course experiments\, we are faced with a need to characterize the observed cellular behaviors over time.  I will present a model that builds on previous approaches to produce cell state trajectories that emphasize the variation between cell lines and treatments.  The resulting approach provides another means to generate hypotheses about the underlying drivers of behavior from global trends in the collected data.
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-igor-nikolskiy-wollman/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Igor-Nikolskiy.jpg
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DTSTART;TZID=America/Los_Angeles:20210219T110000
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DTSTAMP:20260518T075340
CREATED:20210128T192151Z
LAST-MODIFIED:20210222T150500Z
UID:16307-1613732400-1613734200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Maria Izabel Alves Cavassim (Lohmueller)
DESCRIPTION:TITLE: The evolution and co-evolution of PRDM9 across vertebrates \nABSTRACT: In sexually reproducing organisms\, meiotic recombination is initiated by the deliberate infliction of numerous double-strand breaks (DSBs) in the genome\, the repair of which yields crossover and non-crossover resolutions. In most mammals\, these DSBs are specified through the binding of PRDM9 and the deposition of H3K4me3 and H3K36me3 marks. Despite its evolutionary importance\, PRDM9 has been independently lost numerous times across vertebrate’s evolution. Here\, we take advantage of the multiple independent PRDM9 losses to infer the co-evolution of PRDM9 with other meiosis-related genes. \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/01/Maria-Izabel-Alves-Cavassim-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-maria-izabel-alves-cavassim-lohmueller/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/png:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Maria-Izabel-Alves-Cavassim.png
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