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X-WR-CALNAME:Institute for Quantitative and Computational Biosciences
X-ORIGINAL-URL:https://qcb.ucla.edu
X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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DTSTART;TZID=America/Los_Angeles:20210226T110000
DTEND;TZID=America/Los_Angeles:20210226T113000
DTSTAMP:20260518T065729
CREATED:20210106T171458Z
LAST-MODIFIED:20210226T202400Z
UID:15673-1614337200-1614339000@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Amandine Gamble (Lloyd-Smith)
DESCRIPTION:TITLE: “Linking exposure dose to infectious disease development using mechanistic models” (using SARS-CoV-2 in a mouse model as an illustration) \nABSTRACT: Disease development after exposure to a pathogen does not follow a yes/no process\, but rather a spectrum of disease manifestations influenced by host\, pathogen and environmental factors. In particular\, exposure dose can impact incubation time\, shedding intensity and disease severity. However\, classical dose-response models only consider the probability of disease development\, neglecting the diversity of disease manifestations. In contrast\, more complex within-host models are generally parameterized with invasive data\, limiting their potential applications. I will present a modelling framework of the dose-dependence of disease development probability and incubation time using non-invasive data\, illustrated by experimental data collected in rodents exposed to SARS-CoV-2\, and the potential applications of such models. \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/01/Amandine-Gamble-edited.mp4\n 
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-amandine-gamble-lloyd-smith/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Amandine-Gamble.jpg
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DTSTART;TZID=America/Los_Angeles:20210226T113000
DTEND;TZID=America/Los_Angeles:20210226T120000
DTSTAMP:20260518T065730
CREATED:20210217T164027Z
LAST-MODIFIED:20210217T164031Z
UID:16662-1614339000-1614340800@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Will Shoemaker (Garud)
DESCRIPTION:TITLE: “Inferring positive selection in the human gut microbiome using signatures of genetic linkage.” \nABSTRACT: The human gut microbiome is composed of hundreds of simultaneously evolving species that can affect human health. However\, fundamental features of genetic diversity have yet to be leveraged to identify genes that contribute towards microbial adaptation. One such feature is the statistical association of mutations\, otherwise known as linkage disequilibria. In this seminar\, I will describe how patterns of linkage disequilibria can reflect the direction of selection in microbial populations. I will then demonstrate how linkage can provide insight into the degree of positive and negative selection as well as the targets of adaptation across human microbiomes. Finally\, I will compare patterns of linkage disequilibria across hosts to the co-occurrence of mutations within a host. In sum\, the ability to examine linkage among large cohorts for many species provides an opportunity for researchers to examine novel patterns that are indicative of certain evolutionary dynamics.
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-will-shoemaker-garud/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/02/Will-Shoemaker.jpeg
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