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DTSTART;TZID=America/Los_Angeles:20210409T110000
DTEND;TZID=America/Los_Angeles:20210409T113000
DTSTAMP:20260518T045858
CREATED:20210323T144802Z
LAST-MODIFIED:20210409T225858Z
UID:17601-1617966000-1617967800@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Casey Barkan (Wang)
DESCRIPTION:TITLE: “Critical slowing down signals quasi-species extinction in an evolutionary model with environmental heterogeneity.” \nABSTRACT: Environmental heterogeneity can significantly affect the evolutionary dynamics of a population. A key parameter that determines the influence of heterogeneity is the migration rate–the rate at which organisms explore their heterogeneous environment. We study a model of a population which migrates between two habitats that exert distinct selection pressure on the population. We find that the system undergoes multiple phase transitions\, each associated with the extinction of a quasispecies. The dynamics exhibit critical slowing down near each transition. Our results may be relevant to the evolution of antibiotic resistance in bacteria and evolution of gut microbiota. \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/03/Casey-Barkan-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-casey-barkan-wang/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/03/Casey-Barkan.jpg
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DTSTART;TZID=America/Los_Angeles:20210409T113000
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DTSTAMP:20260518T045858
CREATED:20210323T144940Z
LAST-MODIFIED:20210409T195622Z
UID:17604-1617967800-1617969600@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Aliya Lakhani (Park)
DESCRIPTION:TITLE: “Integrating metabolomics and fluxomics to study cancer metabolism in low glucose environments.” \nABSTRACT: Metabolomics and fluxomics are integral tools for quantitative metabolic analysis. By combining mass spectrometry\, isotope tracing\, and mathematical modeling\, we can quantify metabolite concentrations and fluxes in cancer cells. Using these tools\, we are investigating the coordination of bioenergetics\, biosynthesis\, and redox metabolism of cancer cells in the tumor microenvironment. We hypothesize that the tumor microenvironment plays a significant role in dictating cancer cell survival and proliferation. To shed light on how cancer cells use the tumor microenvironment\, we assessed their adaptability to high levels of lactate. While cancer cells did not have a growth advantage over healthy cells in the high-lactate environment\, we found that an intermittent supply of glucose allowed cancer cells to proliferate faster than healthy cells. By tracing stable isotopes from lactate and glutamine across metabolism\, we elucidate the role of lactate in cancer cell survival via gluconeogenesis and energy metabolism. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/03/Aliya-Lakhani-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-aliya-lakhani-park/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/03/Aliya-Lakhani.jpeg
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