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X-WR-CALNAME:Institute for Quantitative and Computational Biosciences
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X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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DTSTART;TZID=America/Los_Angeles:20210430T110000
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SUMMARY:QCBio Research Seminar: Ashfaq Ahmed (Venugopal)
DESCRIPTION:TITLE: “Mechanisms of robust entrainment of biological oscillators involved in gastric peristalsis.”\nABSTRACT: Oscillator entrainment is a widely observed phenomenon in natural systems. Using a computational modeling approach\, we decipher the essential intrinsic and extrinsic mechanisms of robust entrainment of biological oscillators involved in gastric peristalsis. Specifically\, we show that the constitutive intercellular IP3-facilitated pacemaker pathway in these cells stabilizes cellular frequencies\, extends longitudinal entrainment range\, and enables rostro-caudal spread of a gastric slow-wave in a realistic multi-cellular coupled network. Our comprehensive model and the novel predictions offer directions for future experiments and theoretical work. \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/04/Ashfaq-Ahmed-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-ashfaq-ahmed-venugopal/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/04/Ashfaq-Ahmed.jpg
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DTSTART;TZID=America/Los_Angeles:20210430T113000
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CREATED:20210331T002943Z
LAST-MODIFIED:20210504T033951Z
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SUMMARY:QCBio Research Seminar: Alexis Weber (Geschwind & de la Torre-Ubieta)
DESCRIPTION:TITLE: “Defining chromatin accessibility and molecular dysregulation in Down Syndrome.” \nABSTRACT: Despite accumulating almost two centuries of medical information\, the exact mechanisms underlying Down Syndrome (DS) developmental pathology remain unknown. DS is caused by trisomy of chromosome21 (T21)\, but without pinpointing the way in which T21 confers molecular dysfunctions and subsequently impairs neurodevelopment\, it has been difficult to devise medical interventions that will reduce cognitive deficits.  In order to identify these mechanisms in DS and deconvolute the inherent complexity of the developing brain\, we are leveraging single cell technologies to contrast DS and healthy expression profiles and chromatin accessibility in midgestation brain tissue and patient-derived primary human neural progenitor cells (phNPCs). Based on previous bulk RNA and chromatin analyses in DS samples and our preliminary data\, we anticipate 1) changes in cell composition and 2) altered gene-regulatory networks affecting neurogenesis pathways in neural progenitors\, oligodendrocyte precursor cells\, and astrocytes. By uncovering these cytological and molecular aberrations\, we hope to progress the understanding of neurodevelopment and DS to promote medical advances in the future. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/03/Alexis-Weber-edited-1.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-alexis-weber-geschwind-de-la-torre-ubieta/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/png:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/03/HG-Weber.png
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