BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Quantitative and Computational Biosciences - ECPv6.16.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Institute for Quantitative and Computational Biosciences
X-ORIGINAL-URL:https://qcb.ucla.edu
X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20200308T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20201101T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211103T120000
DTEND;TZID=America/Los_Angeles:20211103T123000
DTSTAMP:20260518T005243
CREATED:20211019T215840Z
LAST-MODIFIED:20211020T213535Z
UID:19723-1635940800-1635942600@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Alexander Markowitz (Boutros)\, Postdoc in Human Genetics
DESCRIPTION:TITLE: “A pan-cancer multi-omic analysis of tumor proliferation.” \nABSTRACT: The underlying mechanisms of dysregulated cellular proliferation in cancer remain unclear; however\, it is hypothesized that specific mutations\, mutational signatures\, evolutionary trajectories and other global (epi)genomic features may be linked to differing rates of proliferation. In this presentation\, I will showcase a landscape analysis of cellular proliferation across primary cancers and cell lines using genome\, transcriptome and proteome data from 11\,597 primary tumors and 1\,804 cell lines across six major consortia.  The approach is to develop computational pipelines that will take in next-generation sequenced\, multi-omic datasets from an expanding source of consortia\, apply rigorous statistical methods to test multiple hypotheses on the global\, functional and pharmacogenomics of tumor proliferation and output detailed integration analyses on the underlying genomics of tumor proliferation.  By evaluating proliferation at these molecular levels\, key insights will be yielded including expansive new resources on the variation of proliferation rate across and within cancer types. \nFor lunch at 12:30pm with the speaker\, please RSVP at qcboffice@lifesci.ucla.edu
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-alexander-markowitz-boutros-postdoc-in-human-genetics/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/10/IMG_0679.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211103T130000
DTEND;TZID=America/Los_Angeles:20211103T133000
DTSTAMP:20260518T005243
CREATED:20211020T212859Z
LAST-MODIFIED:20211105T032035Z
UID:19760-1635944400-1635946200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Ricky Wolff (Garud)\, Graduate Student in Ecology & Evolutionary Biology
DESCRIPTION:TITLE: “Ecological Stability Emerges at the Level of Strains in the Human Gut Microbiome.” \nABSTRACT: The human gut microbiome is a complex community that harbors substantial ecological diversity at the species level\, as well as at the strain level within species. In healthy hosts\, species abundance fluctuations in the microbiome community are thought to be stable\, and these fluctuations can be described by macroecological laws. However\, it is less clear how strain abundances change over time. An open question is whether individual strains behave like species themselves\, exhibiting stability and following the macroecological relationships known to hold at the species level\, or whether strains have different dynamics\, perhaps due to the relatively close phylogenetic relatedness of co-colonizing lineages. In this study\, we sought to characterize the typical strain-level dynamics of the healthy human gut microbiome on timescales ranging from days to years. We show that genetic diversity within almost all species is stationary\, tending towards a long-term typical value within hosts over time scales of several years\, despite fluctuations on shorter timescales. Moreover\, the abundance fluctuations of strains can be sufficiently described by a stochastic logistic model (SLM) – a model used to describe abundance fluctuations among species around a fixed carrying capacity – in the vast majority of cases\, suggesting that strains are dynamically stable. Lastly\, we find that strain abundances follow the same macroecological laws known to hold at the species level. Together\, our results suggest that macroecological properties of the human gut microbiome\, including its stability\, emerge at the level of strains. \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/10/Ricky-Wolff.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-ricky-wolff-garud-graduate-student-in-ecology-evolutionary-biology/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/10/Ricky-Wolff.jpeg
END:VEVENT
END:VCALENDAR