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X-WR-CALNAME:Institute for Quantitative and Computational Biosciences
X-ORIGINAL-URL:https://qcb.ucla.edu
X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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DTSTART;TZID=America/Los_Angeles:20211117T120000
DTEND;TZID=America/Los_Angeles:20211117T123000
DTSTAMP:20260518T032616
CREATED:20211005T013231Z
LAST-MODIFIED:20211117T223513Z
UID:19200-1637150400-1637152200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Chloe Yap (Gandal)\, Visiting Graduate Student\, University of Queensland
DESCRIPTION:TITLE: “Restricted diet drives autism gut-microbiome associations\, and other tales from the Australian Autism Biobank” \nABSTRACT: The Australian Autism Biobank (AAB) is an initiative of the Autism CRC – the first national\, cooperative research effort focused on autism across the lifespan. The AAB recruited a total of ~2\,500 autistic children\, family members\, and unrelated undiagnosed children\, and couples deep phenotypic information with multi-omic datasets (SNP genotyping\, stool metagenomics\, DNA methylation\, metabolomics\, WGS). One particularly controversial area in the field has been the potential causal contribution of the gut microbiome to autism. I will present results from one of the largest metagenomics study of the autism stool microbiome to date (n=246\, including 99 children diagnosed with autism). We propose a model whereby microbiome changes in autistic children may reflect consequences of behaviour and dietary preferences\, and we caution against undue emphasis on the microbiome having an upstream role in autism. \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/10/Chloe-Yap.mp4\n 
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-chloe-yap-visiting-graduate-student-university-of-queensland/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/10/Chloe-Yap.jpg
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DTSTART;TZID=America/Los_Angeles:20211117T130000
DTEND;TZID=America/Los_Angeles:20211117T133000
DTSTAMP:20260518T032616
CREATED:20210930T174023Z
LAST-MODIFIED:20211117T223438Z
UID:19185-1637154000-1637155800@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Paheli Desai-Chowdhry (Savage)\, Grad student in Biomathematics
DESCRIPTION:TITLE: “Asymmetric Branching Scale Factors as Features in Neuronal Cell-Type Classification” \nABSTRACT: Neurons are connected by complex branching processes – axons and dendrites – that process information for organisms to respond to their environment. Classifying neurons according to differences in structure or function is a fundamental piece of neuroscience. In previous work\, we constructed a biophysical theory that establishes a correspondence between neuron structure and function as mediated by principles such as time or power minimization\, using undetermined Lagrange multipliers to predict scaling ratios for axon and dendrite sizes across branching levels. Here\, we relax the assumption of symmetrical branching in the model to determine asymmetric branching powers that differ across different cell types due to functional tradeoffs. Furthermore\, we use scale factors related to asymmetric branching as features in machine learning classification to distinguish between different cell types. We find significant distinctions in the asymmetric scaling ratios between Purkinje cells and motoneurons. The performance of these classification methods gives us important insights into the correspondence between structure and function across different cell types. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/09/Paheli-Desai-Chowdhri.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-paheli-desai-chowdhry-savage-grad-student-in-biomathematics/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/09/Paheli-Desai-Chowdhry.jpg
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