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DTSTART;TZID=America/Los_Angeles:20220708T160000
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DTSTAMP:20260517T145529
CREATED:20220629T223906Z
LAST-MODIFIED:20220719T144039Z
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SUMMARY:QCBio/BIG Summer Research Seminar: Dr. Nandita Garud\, Assistant Professor Assistant Professor\, Department of Ecology and Evolutionary Biology\, UCLA
DESCRIPTION:TITLE: “Evolutionary dynamics in the human gut microbiome from infancy through adulthood.” \nABSTRACT: While the ecological dynamics of the infant gut microbiome have been intensely studied\, relatively little is known about the evolutionary dynamics in the infant gut microbiome. Here we analyze longitudinal fecal metagenomic data from >700 infants and their mothers over the first year of life and find that the evolutionary dynamics in infant gut microbiomes are distinct from that of adults. We find evidence for almost 100-fold increase in the rate of evolution and strain turnover in the infant gut compared to healthy adults\, with the mother-infant transition at delivery being a particularly dynamic period in which gene loss dominates. Within a few months after birth\, these dynamics stabilize\, and gene gains become increasingly frequent as the microbiome matures. We furthermore find that evolutionary changes in infants show signatures of being seeded by a mixture of de novo mutations and transmissions of pre-evolved lineages from the broader family. Several of these evolutionary changes occur in parallel in multiple infants\, highlighting candidate genes that may play important roles in the development of the infant gut microbiome. Our results point to a picture of a volatile infant gut microbiome characterized by rapid evolutionary and ecological change in the early days of life.
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-in-collaboration-with-big-summer-dr-nandita-garud-assistant-professor-assistant-professor-department-of-ecology-and-evolutionary-biology-ucla/
LOCATION:Boyer 159\, 611 Charles E. Young Dr. E.\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2022/06/Nandita-Garud.jpg
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