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X-WR-CALNAME:Institute for Quantitative and Computational Biosciences
X-ORIGINAL-URL:https://qcb.ucla.edu
X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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DTSTART;TZID=America/Los_Angeles:20230310T120000
DTEND;TZID=America/Los_Angeles:20230310T123000
DTSTAMP:20260517T033300
CREATED:20230304T013617Z
LAST-MODIFIED:20230310T233042Z
UID:24486-1678449600-1678451400@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Daniel Ha (Yang)\, Postdoc\, Dept. Integrative Biology and Physiology
DESCRIPTION:TITLE: ““Cross-tissue multiomics studies reveal gutbrain interactions mediating the effect of Akkermansia muciniphila in counteracting fructose-induced obesity” \nABSTRACT: The gut bacterium Akkermansia muciniphila (A. muciniphila) has been implicated in anti-obesity effects\, but a systems level understanding of the molecular mechanisms is lacking. We carried out multiomics studies to investigate the molecular cascades mediating the anti-obesity effect of A. muciniphila in a fructoseinduced obesity mouse model. We found that A. muciniphila colonization triggered significant shifts in gut microbiota composition\, gut and plasma metabolites\, and gene expression in hypothalamic neurons. Multiomics integration and network analysis prioritized the metabolite oleoylethanolamide (OEA) in the gut and circulation as a regulator of gut-brain interactions that underlie the A. muciniphila antiobesity effect. Oral administration of OEA counteracted the fructose-induced obesity through the regulation of hypothalamic anorexigenic neuropeptides such as oxytocin and arginine vasopressin. Our multiomics investigation and experimental validation elucidates the molecular regulators and pathways involved in the communication between A. muciniphila in the gut and hypothalamic neurons that counter fructose-induced obesity. \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2023/03/Daniel-Ha-3.10.23.mp4\n 
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-daniel-ha-yang-postdoc-dept-integrative-biology-and-physiology/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2023/03/headshot_photo-1-180x180-DanHa-copy.jpg
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DTSTART;TZID=America/Los_Angeles:20230310T123000
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DTSTAMP:20260517T033300
CREATED:20230304T013953Z
LAST-MODIFIED:20230310T223250Z
UID:24493-1678451400-1678453200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Brandon Tsai (Boutros)\, Grad Student\, Human Genetics
DESCRIPTION:TITLE: “Exercise and tumor genomic landscapes in 2\,702 patients with cancer” \nABSTRACT: Approximately two-thirds of cancer diagnoses globally are attributed to modifiable lifestyle factors such as smoking\, diet and inactivity. Conversely\, regular exercise is linked to decreased risk of multiple cancers. However\, the underlying molecular mechanisms are not fully elucidated. Specifically\, how exercise impacts tumor genomic landscapes has not been considered. To address this gap\, we integrated clinical annotation of exercise exposure with tumor mutational profiling of 2\,702 patients with cancer. Exercise exposure was evaluated by validated questionnaire and tumor genomic profiling of ≥ 505 commonly mutated cancer genes was performed using the Memorial Sloan Kettering Cancer Center Integrated Mutation Profiling of Actional Cancer Targets (MSK-IMPACT) assay. Among the most represented cancer types were breast (n = 629)\, lung (n = 525)\, endometrial (n = 260)\, colorectal (n = 213) and prostate (n = 177). We found that exercise influences the genomic landscapes of tumors in a cancer-type specific manner. For instance\, breast and lung cancers from exercising patients had lower tumor mutation burden (TMB) compared with non-exercisers. A pan-cancer analysis revealed a higher risk ratio among exercisers for mutations in ERBB2 and lower risk ratio for mutations in PIK3CA and CDKN2A. Overall\, this study shows that exercise regulates tumor genomic landscapes in a cancer-site specific manner. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2023/03/Brandon-Tsai-31023.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-brandon-tsai-boutros-grad-student-human-genetics/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2023/03/KGD_8087.jpg
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