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X-WR-CALNAME:Institute for Quantitative and Computational Biosciences
X-ORIGINAL-URL:https://qcb.ucla.edu
X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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DTSTART;TZID=America/Los_Angeles:20241022T123000
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DTSTAMP:20260516T075645
CREATED:20241011T162102Z
LAST-MODIFIED:20241011T162102Z
UID:27013-1729600200-1729603800@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Rizal Hariadi\, Associate Professor\, Department of Physics and Biodesign Institute\, Arizona State University
DESCRIPTION:TITLE: Sensing and applying multi-axial tension to biomolecules using molecular devices built from DNA. \nABSTRACT: DNA nanotechnology enables the construction of molecular devices for diverse biomedical applications. By leveraging DNA’s exquisite positional control\, researchers can engineer sophisticated nanostructures that execute a range of tasks. In this talk\, I will present 2 DNA-based devices: an amphiphilic double-stranded DNA sensor for non-destructive detection of cytosolic biomarkers and a DNA origami platform for multi-axial mechanical manipulation of biomolecules. In the first part of my talk\, I will show synthetic transmembrane devices inspired by G protein-coupled receptors (GPCRs) that transduce signals across cell membranes. These amphiphilic DNA nanodevices detect specific intracellular oligonucleotides\, generating fluorescent signals without cell lysis and genetic engineering. In the second half of the talk\, I will present some recent results on a Holliday junction\, a model system in biophysics\, under multi-axial tension using the Multi-Axial Entropic Spring Tweezer along Rigid Origami (MAESTRO). This molecular tool\, which exploits the entropic elasticity of single-stranded DNA\, uncovers the non-ergodicity of Holliday junction dynamics. The talk concludes with a discussion on the potential applications of these devices\, including their use in high-throughput single-molecule biophysics of integrin signaling\, cryo-EM structural studies of integrins under tension\, and live-cell isolation targeting RNA markers.
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-rizal-hariadi-associate-professor-department-of-physics-and-biodesign-institute-arizona-state-university/
LOCATION:Boyer Hall 159
CATEGORIES:QCBio Seminar Series,Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2024/10/Rizal_Hariadi.jpg
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