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X-WR-CALDESC:Events for Institute for Quantitative and Computational Biosciences
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20200626T120000
DTEND;TZID=America/Los_Angeles:20200626T123000
DTSTAMP:20260519T113158
CREATED:20200626T153823Z
LAST-MODIFIED:20200626T153823Z
UID:13046-1593172800-1593174600@qcb.ucla.edu
SUMMARY:QCBio Research Seminars in Collaboration with B.I.G. Summer : Richard Ahn
DESCRIPTION:“Gene Expression Dynamics in Kidney Transplantation Patients with Cytomegalovirus Viremia”
URL:https://qcb.ucla.edu/event/qcbio-research-seminars-in-collaboration-with-b-i-g-summer-richard-ahn/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/06/Richard-Ahn.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20200710T120000
DTEND;TZID=America/Los_Angeles:20200710T123000
DTSTAMP:20260519T113158
CREATED:20200626T154219Z
LAST-MODIFIED:20200714T231855Z
UID:13050-1594382400-1594384200@qcb.ucla.edu
SUMMARY:QCBio Research Seminars in Collaboration with B.I.G. Summer: Daniel Geschwind\, MD\, PhD
DESCRIPTION:“Using transcriptomic networks to identify new pathways and drugs in brain diseases” \n\nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/06/Daniel-Geschwind.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminars-in-collaboration-with-b-i-g-summer-daniel-geschwind-md-phd/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/06/Daniel-Geschwind-M.D.-Ph.D-USE1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20200717T120000
DTEND;TZID=America/Los_Angeles:20200717T123000
DTSTAMP:20260519T113158
CREATED:20200626T154542Z
LAST-MODIFIED:20201017T161949Z
UID:13054-1594987200-1594989000@qcb.ucla.edu
SUMMARY:QCBio Research Seminars in Collaboration with B.I.G. Summer: Xia Yang
DESCRIPTION:“Multitissue Multiomics Systems Biology of Complex Diseases” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/06/Xia-Yang.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminars-in-collaboration-with-b-i-g-summer-xia-yang/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/06/Yang_Xia_08-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20200724T120000
DTEND;TZID=America/Los_Angeles:20200724T123000
DTSTAMP:20260519T113158
CREATED:20200626T155211Z
LAST-MODIFIED:20200727T163053Z
UID:13060-1595592000-1595593800@qcb.ucla.edu
SUMMARY:QCBio Research Seminars in Collaboration with B.I.G. Summer: Nandita Garud
DESCRIPTION:“Detection of Hard and Soft Selective Sweeps from Population Genomic Data” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/06/Nandita-Garud.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminars-in-collaboration-with-b-i-g-summer-nandita-garud/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/png:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/06/yVCDw8vF.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20200731T120000
DTEND;TZID=America/Los_Angeles:20200731T123000
DTSTAMP:20260519T113158
CREATED:20200626T160445Z
LAST-MODIFIED:20200804T173227Z
UID:13064-1596196800-1596198600@qcb.ucla.edu
SUMMARY:QCBio Research Seminars in Collaboration with B.I.G. Summer: Xinshu (Grace) Xiao
DESCRIPTION:“Isoform and Sequence Diversity in RNA: Genetic Basis and Beyond” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/06/Grace-Xiao.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminars-in-collaboration-with-b-i-g-summer-xinshu-grace-xiao/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/06/XinshuGraceXiaophoto_fd6a2992-2a12-49f0-8026-8d4b2f81b09f-prv.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20200807T120000
DTEND;TZID=America/Los_Angeles:20200807T123000
DTSTAMP:20260519T113158
CREATED:20200626T160815Z
LAST-MODIFIED:20200809T014839Z
UID:13068-1596801600-1596803400@qcb.ucla.edu
SUMMARY:QCBio Research Seminars in Collaboration with B.I.G. Summer: Eleazar Eskin
DESCRIPTION:“UCLA’s Genomics and AI efforts against COVID-19” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/06/Eleazar-Eskin-3.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminars-in-collaboration-with-b-i-g-summer-eleazar-eskin/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/06/eskin-headshot.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201016T110000
DTEND;TZID=America/Los_Angeles:20201016T113000
DTSTAMP:20260519T113158
CREATED:20201008T142919Z
LAST-MODIFIED:20201022T165918Z
UID:14074-1602846000-1602847800@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Dongyuan Song (Li JJ)
DESCRIPTION:“PseudotimeDE: inference of differential gene expression along cell pseudotime with valid p-values from single-cell RNA sequencing data” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Dongyuan-Song-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-dongyuan-song-li-jj/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Dongyuan_Song_Bioinfo-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201016T113000
DTEND;TZID=America/Los_Angeles:20201016T120000
DTSTAMP:20260519T113158
CREATED:20201008T143139Z
LAST-MODIFIED:20201022T170005Z
UID:14078-1602847800-1602849600@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Ning Wang (Hoffmann)
DESCRIPTION:“Identifying the gene regulatory strategies for immune response genes” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Ning-Wang-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-ning-wang-hoffmann/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Ning-Wang.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201023T110000
DTEND;TZID=America/Los_Angeles:20201023T113000
DTSTAMP:20260519T113158
CREATED:20201014T155345Z
LAST-MODIFIED:20201023T233534Z
UID:14231-1603450800-1603452600@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Marc Creixell (Meyer)
DESCRIPTION:“Modeling global phosphoproteomic changes driving AXL-mediated resistance to EGFR-targeted therapies in lung cancer” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Marc-Creixell.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-marc-creixell-meyer/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Marc-Creixell.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201023T113000
DTEND;TZID=America/Los_Angeles:20201023T120000
DTSTAMP:20260519T113158
CREATED:20201014T155606Z
LAST-MODIFIED:20201023T233730Z
UID:14235-1603452600-1603454400@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Christa Caggiano (Zaitlen)
DESCRIPTION:“Comprehensive estimation of the cell type of origin of circulating cell-free DNA” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Christa-Caggiano.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-christa-caggiano-zaitlen/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/png:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Christa-Caggiano.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201030T110000
DTEND;TZID=America/Los_Angeles:20201030T113000
DTSTAMP:20260519T113158
CREATED:20201016T144848Z
LAST-MODIFIED:20201031T081200Z
UID:14325-1604055600-1604057400@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Marta Shocket (Savage)
DESCRIPTION:“How Does Temperature Affect Mosquito Metabolism and Population Growth?” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Marta-Shocket.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-marta-shocket-savage/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/MartaShocketReferencePicture3.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201030T113000
DTEND;TZID=America/Los_Angeles:20201030T120000
DTSTAMP:20260519T113158
CREATED:20201008T143943Z
LAST-MODIFIED:20201008T143943Z
UID:14086-1604057400-1604059200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Nicholas Bayley (Graeber & Nathanson)
DESCRIPTION:“Brain microenvironment-driven transcriptional diversity and plasticity in patient tumors and model systems of glioma”
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-nicholas-bayley-graeber-nathanson/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Nicholas-Bayley.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201106T110000
DTEND;TZID=America/Los_Angeles:20201106T113000
DTSTAMP:20260519T113158
CREATED:20201021T155802Z
LAST-MODIFIED:20201108T152515Z
UID:14380-1604660400-1604662200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Henan Zhu (Graeber & Nathanson)
DESCRIPTION:“Learning from mistakes: how to achieve a comprehensive tumor genetic profile based on whole-exome sequencing” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Zenan-Zhu-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-henan-zhu-graeber-nathanson/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/henan_zhu-e1553560998838-1.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201106T113000
DTEND;TZID=America/Los_Angeles:20201106T120000
DTSTAMP:20260519T113158
CREATED:20201014T161310Z
LAST-MODIFIED:20201108T152603Z
UID:14247-1604662200-1604664000@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Leihao Wei (Hsu)
DESCRIPTION:“Enhancing Medical Images to Improve the Reproducibility of Quantitative Image Features to Correlate with Biological Processes” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Leihao-Wei-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-leihao-wei-hsu/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/0-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201113T110000
DTEND;TZID=America/Los_Angeles:20201113T113000
DTSTAMP:20260519T113158
CREATED:20201022T010614Z
LAST-MODIFIED:20201105T155423Z
UID:14395-1605265200-1605267000@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Arash Bellafard (Golshani)
DESCRIPTION:“The stability of population dynamics underlying working memory”
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-arash-bellafard-golshani/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Arash-Bellafard.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201113T113000
DTEND;TZID=America/Los_Angeles:20201113T120000
DTSTAMP:20260519T113158
CREATED:20201022T183102Z
LAST-MODIFIED:20201114T163044Z
UID:14411-1605267000-1605268800@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Nan Miles Xi (Li JJ)
DESCRIPTION:“Benchmarking computational doublet-detection methods for single-cell RNA sequencing data” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Nan-Miles-Xi-Edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-nan-miles-xi-li-jj/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Nan-Miles-Xi.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201120T110000
DTEND;TZID=America/Los_Angeles:20201120T113000
DTSTAMP:20260519T113158
CREATED:20201017T153555Z
LAST-MODIFIED:20201120T210742Z
UID:14336-1605870000-1605871800@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Tianyi Sun (Li JJ)
DESCRIPTION:“scDesign2: an interpretable simulator that generates realistic single-cell gene expression count data with gene correlations captured” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Tianyi-Sun-edited-1.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-tianyi-sun-li-jj/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/png:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Tianyi_Sun_image.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201120T113000
DTEND;TZID=America/Los_Angeles:20201120T120000
DTSTAMP:20260519T113158
CREATED:20201014T160449Z
LAST-MODIFIED:20201120T210658Z
UID:14244-1605871800-1605873600@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Paheli Desai-Chowdhry (Savage)
DESCRIPTION:“Scaling Theory in Axons and Dendrites”  \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Paheli-Desai-Chowdhry-edited-1.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-paheli-desai-chowdhry-savage/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Paheli-Desai-Chowdhry.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201204T110000
DTEND;TZID=America/Los_Angeles:20201204T113000
DTSTAMP:20260519T113159
CREATED:20201014T155903Z
LAST-MODIFIED:20201204T204520Z
UID:14239-1607079600-1607081400@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Yiling Chen (Li JJ)
DESCRIPTION:“APIR: a flexible and powerful FDR control framework for aggregating peptide identification results” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Yiling-Chen-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-yiling-chen-li-jj/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Yiling-Chen-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201204T113000
DTEND;TZID=America/Los_Angeles:20201204T120000
DTSTAMP:20260519T113159
CREATED:20201027T125842Z
LAST-MODIFIED:20201204T204646Z
UID:14470-1607081400-1607083200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Nitika Sharma (Pinter-Wollman)
DESCRIPTION:“A reproductive heir has a central position in multilayer social networks of primitively eusocial paper wasps” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Nitika-Sharma-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-nitika-sharma-pinter-wollman/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Nitika-Sharma.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201211T110000
DTEND;TZID=America/Los_Angeles:20201211T113000
DTSTAMP:20260519T113159
CREATED:20201025T182423Z
LAST-MODIFIED:20201211T205444Z
UID:14459-1607684400-1607686200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Alex Fisher (Suchard)
DESCRIPTION:“Shrinkage-based random local clocks with scalable inference” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Alex-Fisher-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-alex-fisher-suchard/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Alex-Fisher.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20201211T113000
DTEND;TZID=America/Los_Angeles:20201211T120000
DTSTAMP:20260519T113159
CREATED:20201023T234149Z
LAST-MODIFIED:20201211T205539Z
UID:14453-1607686200-1607688000@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Nathan LaPierre (Eskin)
DESCRIPTION:“MsCAVIAR: Identifying Causal Variants by Fine Mapping Across Multiple Studies” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2020/10/Nathan-LaPierre-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-danielle-graham-kalbasi-graeber-eilber/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2020/10/Nathan-LaPierre-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210108T110000
DTEND;TZID=America/Los_Angeles:20210108T113000
DTSTAMP:20260519T113159
CREATED:20210103T194659Z
LAST-MODIFIED:20210109T154059Z
UID:15374-1610103600-1610105400@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Dino Osmanovic (Franco)
DESCRIPTION:TITLE: “Chemical reactions and condensates” \nABSTRACT: In the past decade\, condensates have been implicated as a mechanism of organization in biological systems. In addition to the potentially biologically relevant aspects of this\, it has also encouraged physicists to revisit some aspects of the classic theories of phase separation\, but now with inclusion of elements that more closely mimic elements of biological reality. In this talk\, I shall present an example of such\, where I will show how simple models of phase separating liquids with the inclusion of non-equilibrium chemical reactions can lead to novel behaviors. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/01/Dino-Osmanovic-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-dino-osmanovic-franco/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/png:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Unknown-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210108T113000
DTEND;TZID=America/Los_Angeles:20210108T120000
DTSTAMP:20260519T113159
CREATED:20210103T195126Z
LAST-MODIFIED:20210113T013242Z
UID:15378-1610105400-1610107200@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Sharmila Venugopal\, Assistant Adjunct Professor\, Integrative Biology and Physiology - PART I
DESCRIPTION:TITLE: “Merging Experimental and Computational Approaches to Study Neurodegenerative Disease Dynamics” \nABSTRACT: Neurodegenerative diseases such as Alzheimer’s and Parkinson’s affect millions of people around the world and are a growing health concern in aging populations. A major roadblock in developing effective treatments involve the diverse etiology and progression rates\, combined with a lack of clear understanding of how disease alters the nervous system. Basic science plays a crucial role in developing a deeper understanding of pre-symptomatic disease mechanisms using animal models of human disease.  Exploiting this opportunity\, our lab has taken a unique stride to merge data-driven computational modeling with diverse experimental approaches to examine the workings of a neural microcircuit and its vulnerability in neurodegeneration. In my talk\, I will discuss our work on computational and mathematical modeling \, use of a biohybrid technique to integrate models into experiments in real-time\, and our novel findings in a devastating neurodegenerative motor neuron disease\, Amyotrophic Lateral Sclerosis\, commonly known as Lou Gehrig’s disease. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/01/Sharmila-Venugopal-edited.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-sharmila-venugopal-assistant-adjunct-professor-integrative-biology-and-physiology/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Sharmila-Venugopal.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210113T090000
DTEND;TZID=America/Los_Angeles:20210113T100000
DTSTAMP:20260519T113159
CREATED:20210114T192138Z
LAST-MODIFIED:20210114T192138Z
UID:15892-1610528400-1610532000@qcb.ucla.edu
SUMMARY:Developmental Systems Biology Faculty Search - MCDB | QCBio | BSCRC Seminar: Adrian Jacobo\, PhD\, The Rockefeller University\, New York\, NY
DESCRIPTION:TITLE: “Symmetry breaking during morphogenesis of a mechanosensory organ” \nABSTRACT: The development of mechanosensory epithelia\, such as those of the auditory and vestibular systems\, results in the precise orientation of mechanosensory hair cells and consequently directional sensitivity. After division of a precursor cell in the zebrafish lateral line\, the daughter hair cells differentiate with opposite mechanical sensitivity. This process produces neuromasts containing equal numbers of hair cells of two opposite polarities\, half of them sensitive to caudad water movement and half to rostrad flow.  \nUsing a combination of experimental tools and mathematical modeling we show how Notch-mediated lateral inhibition produces a bistable switch that reliably gives rise to hair-cell pairs of opposite polarity. This spontaneous symmetry breaking drives polarity-dependent movements of hair cells that lead to the establishment of a mirror-symmetric organization of the organ. We model these reconfigurations by describing the effective surface tensions of the hair cells and the changes in these quantities throughout the developmental process. These results provide a unified experimental and theoretical framework to describe the polarity selection and directed migration of hair cells in the zebrafish lateral line. 
URL:https://qcb.ucla.edu/event/developmental-systems-biology-faculty-search-mcdb-qcbio-bscrc-seminar-adrian-jacobo-phd-the-rockefeller-university-new-york-ny/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Seminar-flyer-Adrian-Jacobo3.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210113T110000
DTEND;TZID=America/Los_Angeles:20210113T120000
DTSTAMP:20260519T113159
CREATED:20210114T192851Z
LAST-MODIFIED:20210114T192851Z
UID:15901-1610535600-1610539200@qcb.ucla.edu
SUMMARY:Developmental Systems Biology Faculty Search - MCDB | QCBio | BSCRC Seminar: Eviatar Yemini\, PhD\, Columbia University\, New York\, NY
DESCRIPTION:TITLE: “Biologist\, Know Thy Cells – A Colorful Barcoding Method to ID Cell Types\, their Fate\, and Decode Brainwide Communication” \nABSTRACT: A major challenge in biological imaging is resolving cell identities. These are necessary for determining cell-specific protein expression and function\, the effect of transcription factors on cell fate\, and the contribution of individual neurons to brainwide activity and behavior. Present methods are limited to a piecemeal approach\, using multiple strains to identify a few cell types at a time. I introduce a new method and software that can identify many cell types\, and in some cases all neurons\, in vivo using a single strain. My method combines cell reporters with five distinguishable fluorescent proteins to create unique\, stereotyped color codes that identify cell types. I illustrate this in C. elegans\, engineering a multicolor transgene called NeuroPAL (a Neuronal Polychromatic Atlas of Landmarks)\, to create an identical colormap in all worms that uniquely identifies every neuron\, showcasing three applications. First\, I identify the neuronal expression patterns of all metabotropic receptors for acetylcholine\, GABA\, and glutamate\, thus completing a map of this communication network. My findings indicate that second-messenger systems are the primary means of GABA communication in worm\, and further suggest widespread extrasynaptic GABA signaling. Second\, I analyze the conserved transcription factor EOR-1/PLZF and\, despite its ubiquitous expression\, uncover a precise role in neuronal fate. Third\, I identify brainwide codes for gustatory and olfactory stimuli. My findings show a complex code that challenges the present view that global neuronal activity is simply low dimensional. To facilitate the workflow\, I present semi-automated cell identification software and optimal-coloring software to apply the same method in other tissues and organisms. Lastly\, I discuss future applications: investigating how whole-nervous-system activity is remodeled to change behavior during early development\, sexual maturation\, in response to environmental stress\, and even across 15+ million years of evolutionary divergence. 
URL:https://qcb.ucla.edu/event/developmental-systems-biology-faculty-search-mcdb-qcbio-bscrc-seminar-eviatar-yemini-phd-columbia-university-new-york-ny/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Seminar-flyer-Eviatar-Yemini5.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210114T120000
DTEND;TZID=America/Los_Angeles:20210114T130000
DTSTAMP:20260519T113159
CREATED:20210114T193401Z
LAST-MODIFIED:20210114T193401Z
UID:15909-1610625600-1610629200@qcb.ucla.edu
SUMMARY:Developmental Systems Biology Faculty Search - MCDB | QCBio | BSCRC Seminar: Hannah Long\, DPhil\, Stanford University\, Stanford\, CA
DESCRIPTION:TITLE: “Enhancer Loss and Gene Dosage Sensitivity Drives a Human Craniofacial Disorder” \nABSTRACT: In recent years\, the importance of understanding the role of non-coding regulatory mutations in human disease has become increasingly apparent. This is illustrated by a hotspot of non-coding mutations at the far end of a large gene desert surrounding the SOX9 gene that result in a human craniofacial disorder called Pierre Robin sequence (PRS). To test whether this locus harbours developmental regulatory elements that are perturbed in PRS patients\, we utilized a well-characterized in vitro differentiation model of facial development. Within the PRS-associated region we identified two clusters of enhancers that regulate SOX9 expression during a restricted window of facial progenitor development\, at distances of up to 1.45 Mb. Enhancers within these clusters exhibit highly synergistic activity that is dependent on the Coordinator motif and TWIST1 binding and are conserved in activity down to Coelacanth fish. We observe dramatic changes in 3D conformation of the SOX9 locus during facial progenitor development and propose a mechanism for extreme long-range gene regulation. Using mouse models\, we demonstrate that specificity of PRS manifestations arises from the convergence of two developmental features: confinement of Sox9 dosage perturbation to the developing facial structures due to context-specific enhancer activity\, and a heightened sensitivity of the lower jaw to Sox9 level reduction. Overall\, we characterize the longest-range human enhancers involved in congenital malformations described to date\, provide molecular insights into disease aetiology to directly classify PRS as an enhanceropathy\, and illustrate how small changes in gene expression can lead to morphological variation. 
URL:https://qcb.ucla.edu/event/developmental-systems-biology-faculty-search-mcdb-qcbio-bscrc-seminar-hannah-long-dphil-stanford-university-stanford-ca/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Seminar-flyer-Hannah-Long2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210115T110000
DTEND;TZID=America/Los_Angeles:20210115T233000
DTSTAMP:20260519T113159
CREATED:20210109T154453Z
LAST-MODIFIED:20210116T161044Z
UID:15752-1610708400-1610753400@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Sharmila Venugopal (Part II)
DESCRIPTION:TITLE: “Merging Experimental and Computational Approaches to Study Neurodegenerative Disease Dynamics” \nABSTRACT: “Neurodegenerative diseases such as Alzheimer’s and Parkinson’s affect millions of people around the world and are a growing health concern in aging populations. A major roadblock in developing effective treatments involve the diverse etiology and progression rates\, combined with a lack of clear understanding of how disease alters the nervous system. Basic science plays a crucial role in developing a deeper understanding of pre-symptomatic disease mechanisms using animal models of human disease.  Exploiting this opportunity\, our lab has taken a unique stride to merge data-driven computational modeling with diverse experimental approaches to examine the workings of a neural microcircuit and its vulnerability in neurodegeneration. In my talk\, I will discuss our work on computational and mathematical modeling \, use of a biohybrid technique to integrate models into experiments in real-time\, and our novel findings in a devastating neurodegenerative motor neuron disease\, Amyotrophic Lateral Sclerosis\, commonly known as Lou Gehrig’s disease.” \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/01/Sharmila-Venugopal-edited-1.mp4
URL:https://qcb.ucla.edu/event/qcbio-research-seminar-sharmila-venugopal-part-ii/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Sharmila-Venugopal.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210115T113000
DTEND;TZID=America/Los_Angeles:20210115T120000
DTSTAMP:20260519T113159
CREATED:20210103T195622Z
LAST-MODIFIED:20210115T220924Z
UID:15384-1610710200-1610712000@qcb.ucla.edu
SUMMARY:QCBio Research Seminar: Cyrillus Tan (Meyer)
DESCRIPTION:TITLE: “A quantitative view of strategies to engineer cell-selective ligand binding” \nABSTRACT: Selective binding to specific target cells is a critical property of many therapies. To enhance selectivity in specific situations\, a series of new strategies have been proposed in the drug development literature\, including affinity\, valency\, multi-specificity\, and other alterations to target cell binding. We have developed a simple and general\, multivalent ligand-receptor binding model that can help to direct therapeutic engineering. Using this model\, we provide generalized and quantitative analyses of the effectiveness and limitations of each strategy. We also demonstrate that combining strategies can offer enhanced selectivity. This work provides guidance for future therapeutic development. \nhttps://qcb.ucla.edu/wp-content/uploads/sites/14/2021/01/Cyrillus-Tan-edited.mp4
URL:https://qcb.ucla.edu/event/research-seminar-cyrillus-tan-meyer/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Cyrillus-Tan.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210115T120000
DTEND;TZID=America/Los_Angeles:20210115T130000
DTSTAMP:20260519T113159
CREATED:20210114T193131Z
LAST-MODIFIED:20210114T193131Z
UID:15905-1610712000-1610715600@qcb.ucla.edu
SUMMARY:Developmental Systems Biology Faculty Search - MCDB | QCBio | BSCRC Seminar: Juan Alvarez\, PhD\, Harvard University\, Cambridge\, MA
DESCRIPTION:TITLE: “Organoid Maturation by Circadian Entrainment “ \nABSTRACT: Stem cell-derived tissues that recap endogenous physiology are key for regenerative medicine. Yet\, most methods yield products that function like fetal\, not adult tissues. Organoids are typically grown in constant environments\, while our tissues mature along with behavioral cycles. I show that inducing circadian rhythms in pancreatic islet organoids\, by entraining them to daily feeding-fasting cycles or “meals”\, elicits their metabolic maturation. The results show that rhythms can be harnessed to further functional maturation of organoids destined for human therapeutics. 
URL:https://qcb.ucla.edu/event/developmental-systems-biology-faculty-search-mcdb-qcbio-bscrc-seminar-juan-alvarez-phd-harvard-university-cambridge-ma/
LOCATION:ZOOM\, CA\, United States
CATEGORIES:Research Seminars
ATTACH;FMTTYPE=image/jpeg:https://wp-misc.lifesci.ucla.edu/qcb/wp-content/uploads/sites/14/2021/01/Seminar-flyer-Juan-Alvarez3.jpg
END:VEVENT
END:VCALENDAR