TITLE: "Chemical reactions and condensates" ABSTRACT: In the past decade, condensates have been implicated as a mechanism of organization in biological systems. In addition to the potentially biologically relevant aspects of […]
TITLE: "Merging Experimental and Computational Approaches to Study Neurodegenerative Disease Dynamics" ABSTRACT: Neurodegenerative diseases such as Alzheimer's and Parkinson's affect millions of people around the world and are a growing […]
TITLE: "Symmetry breaking during morphogenesis of a mechanosensory organ" ABSTRACT: The development of mechanosensory epithelia, such as those of the auditory and vestibular systems, results in the precise orientation of mechanosensory […]
TITLE: "Biologist, Know Thy Cells - A Colorful Barcoding Method to ID Cell Types, their Fate, and Decode Brainwide Communication" ABSTRACT: A major challenge in biological imaging is resolving cell identities. […]
TITLE: "Enhancer Loss and Gene Dosage Sensitivity Drives a Human Craniofacial Disorder" ABSTRACT: In recent years, the importance of understanding the role of non-coding regulatory mutations in human disease has become […]
TITLE: “Merging Experimental and Computational Approaches to Study Neurodegenerative Disease Dynamics” ABSTRACT: "Neurodegenerative diseases such as Alzheimer's and Parkinson's affect millions of people around the world and are a growing health concern […]
TITLE: "A quantitative view of strategies to engineer cell-selective ligand binding" ABSTRACT: Selective binding to specific target cells is a critical property of many therapies. To enhance selectivity in specific […]
TITLE: "Organoid Maturation by Circadian Entrainment " ABSTRACT: Stem cell-derived tissues that recap endogenous physiology are key for regenerative medicine. Yet, most methods yield products that function like fetal, not adult tissues. […]
TITLE: "Building an integrated framework for tissue morphogenesis with the zebrafish inner ear" ABSTRACT: How simple tissues give rise to geometrically complex organs with robust shapes and functions is a fundamental […]
TITLE: "Understanding how environmental cues regulate Neuro-Mesodermal progenitor cells in development and disease" ABSTRACT: The trunk and tail of vertebrates arise from the addition of mesodermal (i.e., muscle and vertebrae) and […]
TITLE: "Cellular plasticity and fate choices in developing tissues and single cancer cells" ABSTRACT: While cellular processes are often reproducible and precise, cells may also alter their molecular states and adopt […]
TITLE: "Exploration of human genetic and phenotypic diversity through cell villages" ABSTRACT: Our species is characterized by an immense diversity in neurological and psychological traits. Common and rare genetic variants have […]
TITLE: "Imaging-based genetic recording of developmental histories" ABSTRACT: Systems-level understanding of cell fate decisions has been hampered by limitations of the existing methods to capture developmental history of the cells. Synthetic […]
TITLE: "Genomewide supervised prediction of activating and repressive regions in over hundred cell and tissue types" ABSTRACT: While the vast majority of variants associated with common disease risk are distributed […]
TITLE: "XIST controls X chromosome dampening and autosomal genes in early human development" ABSTRACT: Female human pre-implantation embryos and naïve human pluripotent stem cells (hPSCs) equalize X-linked gene expression with males […]
TITLE: "Fast estimation of genetic correlation for Biobank-scale data" ABSTRACT: Genetic correlation is an important parameter in understanding the shared genetic basis across pairs of complex traits with applications ranging across […]
TITLE: "Determining mRNA nuclear export kinetics reveals a wide range of values associated with innate immune response genes" ABSTRACT: The abundance and stimulus-responsiveness of mature mRNA is known to be […]