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January 2022

QCBio Research Seminar: Dongyuan Song (Li JJ), Graduate Student in Bioinformatics

January 5, 2022 @ 11:30 am - 12:00 pm
Boyer 159

TITLE: "scDesign3: an all-in-one statistical framework that generates realistic single-cell omics data and infers cell heterogeneity structure." ABSTRACT: The generation of realistic synthetic data is essential for benchmarking numerous computation tools developed for single-cell omics data. Here we propose an all-in-one statistical framework that generates single-cell omics data from various cell heterogeneity structures, including discrete cell types, continuous cell trajectories, and spatial cell locations. Our framework uses a unified probabilistic model with accessible likelihood. This probabilistic formulation is advantageous in that…

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