Loading Events

Upcoming Events › Research Seminars

Events Search and Views Navigation

Event Views Navigation

February 2021

QCBio Research Seminar: Amandine Gamble (Lloyd-Smith)

February 26 @ 11:00 am - 11:30 am
ZOOM CA United States

TITLE: "Linking exposure dose to infectious disease development using mechanistic models" (using SARS-CoV-2 in a mouse model as an illustration) ABSTRACT: Disease development after exposure to a pathogen does not follow a yes/no process, but rather a spectrum of disease manifestations influenced by host, pathogen and environmental factors. In particular, exposure dose can impact incubation time, shedding intensity and disease severity. However, classical dose-response models only consider the probability of disease development, neglecting the diversity of disease manifestations. In contrast, more…

Find out more »

QCBio Research Seminar: Will Shoemaker (Garud)

February 26 @ 11:30 am - 12:00 pm
ZOOM CA United States

TITLE: “Inferring positive selection in the human gut microbiome using signatures of genetic linkage.” ABSTRACT: The human gut microbiome is composed of hundreds of simultaneously evolving species that can affect human health. However, fundamental features of genetic diversity have yet to be leveraged to identify genes that contribute towards microbial adaptation. One such feature is the statistical association of mutations, otherwise known as linkage disequilibria. In this seminar, I will describe how patterns of linkage disequilibria can reflect the direction of…

Find out more »

March 2021

QCBio Research Seminar: Katherine Sheu (Hoffmann)

March 5 @ 11:00 am - 11:30 am
ZOOM CA United States

TITLE: "TBD"

Find out more »

QCBio Research Seminars: Ali Pazokitoroudi (Sankararaman)

March 5 @ 11:30 am - 12:00 pm
ZOOM CA United States

TITLE: "Efficient variance components analysis across millions of genomes." ABSTRACT: While variance components analysis has emerged as a powerful tool in complex trait genetics, existing methods for fitting variance components do not scale well to large-scale datasets of genetic variation. I will present a method for variance components analysis that is accurate and efficient: capable of estimating one hundred variance components on a million individuals genotyped at a million SNPs in a few hours. We illustrate the utility of our method…

Find out more »

QCBio Research Seminar: Alexander Markowitz (Boutros)

March 12 @ 11:30 am - 12:00 pm
ZOOM CA United States

TITLE: "A pan-cancer landscape analysis of molecular and functional genomics in tumor proliferation." ABSTRACT: Rapid proliferation is a central hallmark of cancer and is associated with poor prognosis in most cancer types. My overall goal is to understand the mechanisms by which specific driver mutations and mutational signatures influence rates of tumor proliferation within and between cancer types and subtypes. I will do so by integrating model-system and patient data, providing both descriptive and mechanistic insights into the origins, consequences…

Find out more »

April 2021

QCBio Research Seminars: Zinzhou Ge (Li JJ)

April 2 @ 11:30 am - 12:00 pm
ZOOM CA United States

TITLE: "Clipper: p-value-free FDR control on high-throughput data from two conditions." ABSTRACT: High-throughput biological data analysis commonly involves identifying "interesting" features (e.g., genes, genomic regions, and proteins), whose values differ between two conditions, from numerous features measured simultaneously. The most widely-used criterion to ensure the analysis reliability is the false discovery rate (FDR). Existing bioinformatics tools primarily control the FDR based on p-values. However, obtaining valid p-values relies on either reasonable assumptions of data distribution or large numbers of replicates…

Find out more »
+ Export Events