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November 2021

Bioinformatics/Human Genetics Seminar Series: Katie Peichel, Head of the Division Evolutionary Ecology, University of Bern

November 22 @ 11:00 am - 12:00 pm
ZOOM CA United States

“The role of chromosome evolution in adaptation and speciation in stickleback fish” Hosted by Kirk Lohmueller

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QCBio Research Seminar: Paheli Desai-Chowdhry (Savage), Grad student in Biomathematics

November 17 @ 1:00 pm - 1:30 pm
Boyer 159, 611 Charles E. Young Dr. E.
Los Angeles, CA 90095 United States
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TITLE: "Asymmetric Branching Scale Factors as Features in Neuronal Cell-Type Classification" ABSTRACT: Neurons are connected by complex branching processes - axons and dendrites - that process information for organisms to respond to their environment. Classifying neurons according to differences in structure or function is a fundamental piece of neuroscience. In previous work, we constructed a biophysical theory that establishes a correspondence between neuron structure and function as mediated by principles such as time or power minimization, using undetermined Lagrange multipliers…

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QCBio Research Seminar: Chloe Yap (Gandal), Visiting Graduate Student, University of Queensland

November 17 @ 12:00 pm - 12:30 pm
Boyer 159, 611 Charles E. Young Dr. E.
Los Angeles, CA 90095 United States
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TITLE: "Restricted diet drives autism gut-microbiome associations, and other tales from the Australian Autism Biobank" ABSTRACT: The Australian Autism Biobank (AAB) is an initiative of the Autism CRC – the first national, cooperative research effort focused on autism across the lifespan. The AAB recruited a total of ~2,500 autistic children, family members, and unrelated undiagnosed children, and couples deep phenotypic information with multi-omic datasets (SNP genotyping, stool metagenomics, DNA methylation, metabolomics, WGS). One particularly controversial area in the field has…

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Bioinformatics/Human Genetics Seminar Series: Erick Matsen, Professor, Public Health Sciences Division, Associate Program Head of Herbold Computational Biology Program, Fred Hutchinson Cancer Center

November 15 @ 11:00 am - 12:00 pm
ZOOM CA United States

“Towards Bayesian phylogenetics via systematic search and gradient ascent” Hosted by Sriram Sankararaman

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QCBio Research Seminar: Guo Xiaohui (Pinter-Wollman), Postdoc in Ecology & Evolutionary Biology

November 10 @ 1:00 pm - 1:30 pm
Boyer 159, 611 Charles E. Young Dr. E.
Los Angeles, CA 90095 United States
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TITLE: "Decoding alarm signal propagation of seed-harvester ants, Pogonomyrmex californicus." ABSTRACT: Alarm signal propagation through social-insect colonies provides an empirically tractable context for analyzing information flow through a natural system, with useful insights for network dynamics in other social groups, including human social networks. Here, I develop a methodological approach to track alarm spread within the group of harvester ants, Pogonomyrmex californicus. I alarmed initial 3 individuals and tracked subsequent signal transmission through the group. Because there was no actual…

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QCBio Research Seminar: Mariana Harris Heredia (Garud), Grad student in Biomathematics

November 10 @ 12:00 pm - 12:30 pm
Boyer 159, 611 Charles E. Young Dr. E.
Los Angeles, CA 90095 United States
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TITLE: "Differences in the Signatures of Selection Between the Autosomes and the X Chromosome in Drosophila melanogaster." ABSTRACT: Sex chromosomes in Drosophila are found in a hemizygous state in males. Thus, deleterious mutations may be purged more rapidly on the X chromosome than on the autosomes. This purging can result in less available standing variation that can seed adaptation on the X chromosome. Here, we investigate how differences in the recessivity of alleles on the X chromosome versus autosomes impact the mode and…

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Bioinformatics/Human Genetics Seminar Series: Eimear Kenny, Founding Director, Institute for Genomic Health, Mount Sinai School of Medicine

November 8 @ 11:00 am - 12:00 pm
ZOOM CA United States

“Population genetics in an era of genomic health” Hosted by Christa Caggiano

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QCBio Research Seminar: Ricky Wolff (Garud), Graduate Student in Ecology & Evolutionary Biology

November 3 @ 1:00 pm - 1:30 pm
Boyer 159, 611 Charles E. Young Dr. E.
Los Angeles, CA 90095 United States
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TITLE: "Ecological Stability Emerges at the Level of Strains in the Human Gut Microbiome." ABSTRACT: The human gut microbiome is a complex community that harbors substantial ecological diversity at the species level, as well as at the strain level within species. In healthy hosts, species abundance fluctuations in the microbiome community are thought to be stable, and these fluctuations can be described by macroecological laws. However, it is less clear how strain abundances change over time. An open question is…

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QCBio Research Seminar: Alexander Markowitz (Boutros), Postdoc in Human Genetics

November 3 @ 12:00 pm - 12:30 pm
Boyer 159, 611 Charles E. Young Dr. E.
Los Angeles, CA 90095 United States
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TITLE: "A pan-cancer multi-omic analysis of tumor proliferation." ABSTRACT: The underlying mechanisms of dysregulated cellular proliferation in cancer remain unclear; however, it is hypothesized that specific mutations, mutational signatures, evolutionary trajectories and other global (epi)genomic features may be linked to differing rates of proliferation. In this presentation, I will showcase a landscape analysis of cellular proliferation across primary cancers and cell lines using genome, transcriptome and proteome data from 11,597 primary tumors and 1,804 cell lines across six major consortia.  The…

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