2018 Bruins-In-Genomics Summer Undergraduate Research Program

2018 B.I.G. Summer Alumni Updates

  • September 2018: Congratulations to our 2018 alumni who have been selected by the Annual Biomedical Research Conference for Minority Students (ABRCMS) to present their research from B.I.G. Summer. Ruth Adewale (Howard University ’19), mentored by Dr. Valerie Arboleda, and Janae Lyttle (Spelman College ’19), mentored by Dr. Luisa Iruela-Arispe, will present results from their summer research projects at ABRCMS 2018 in Indianapolis, Indiana.

2018 B.I.G. Summer Best Poster Award Winners

2018 B.I.G. Summer Participants

Lab PIsMentorsStudents
VALERIE ARBOLEDAMaria PalafoxAmy Freiberg, Univ. of Central Florida
Ruth Adewale, Howard University
JASON ERNSTAdriana SperleaBrooke Felsheim, Washington University
Jennifer Chien, Wellesley College
ELEAZAR ESKINRobert BrownJinjing Zhou, UCLA
Sarah Faller, Duke University
Serghei MangulCaitlin Loeffler, UCLA
Emily Wesel, Westlake-Harvard High School
Jacqueline Castellanos, Santa Monica College
Keith Mitchell, UCLA
Ram Ayyala, UCLA
Varuni Sarwal, Indian Institute of Technology
ALEXANDER HOFFMANNQuen ChengKensei Kishimoto, UCLA
Diane LefaudeuxNick Miller, Cornell University, Ithaca
Simon MitchellAmy Tam, UCLA
LUISA IRUELA-ARISPEMilagros RomayJanae Lyttle, Spelman College
Lyndon Rolle, Fisk University
HUIYING LIBaochen ShiDana Franklin, Fisk University
Nnamdi Osakwe, North Carolina Central Univ.
STANLEY NELSONHane LeeKayla Schimke, UC Santa Cruz
Samuel Nkrumah, Fisk University
BENNETT NOVITCHRanmal SamarasingheBrandon Nanfito, UCLA
PÄIVI PAJUKANTAMarcus AlvarezGrant Schulte, UCLA
JEANETTE PAPPBenjamin ChuGordon Mosher, UC Riverside
Marcel Nwaukwa, Univ. of Arkansas at Pine Bluff
BOGDAN PASANIUCKathryn BurchAngela Wei, Univ. of Kentucky
Malika Kumar FreundDaniela Perry, Cornell University
MATTEO PELLEGRINIColin FarrellHuiling Huang, UCLA
Simran Rajpal, UCLA
SRIRAM SANKARARAMANRobert BrownBoyang Fu, Rutgers University
Jingxian (Clara) Liu, Cornell University
Arun DurvasulaElliot Kang, Brown University
Mario Paciuc, Rice University
Ariel WuAnna Yaschenko, Univ. of Maryland, Baltimore Co.
Mohammadreza Hajy Heydary, CSU Fullerton
JAE HOON SULBrandon JewSabrina Iddir, Univ. of Chicago
Huajun ZhouJiangyuan (Jerome) Luo, UCLA
GRACE XIAOKikuye KoyanoElaine Huang, Lafayette College
Michele Ramos Correa, CSU Northridge
JASMINE ZHOUShuo LiEmily Kobayashi, UC Santa Cruz
Jacquelyn Roger, UC Santa Cruz

2018 B.I.G. Summer Poster Abstracts





























ANGELA WEI1, Kathryn Burch2, Claudia Giambartolomei3, Michael Gandal4, Bogdan Pasaniuc3,5,6

1 BIG Summer Program, Institute for Quantitative and Computational Biosciences,
2 Bioinformatics Interdepartmental Program,
3 Department of Pathology and Laboratory Medicine, David Geffen School of Medicine,
4 Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine,
5 Department of Human Genetics, David Geffen School of Medicine,
6 Department of Biomathematics, David Geffen School of Medicine, UCLA

Gene co-expression networks, or modules, are groups of genes that share similar expression patterns. Integrating gene modules with large-scale genetic data can help uncover mechanisms underlying complex diseases, such as psychiatric disorders. Here, we integrate 34 gene and 56 isoform modules obtained from cerebral cortex samples (n=1,322) of patients with autism (ASD), schizophrenia (SCZ), and bipolar disorder (BIP) with genome-wide association studies (GWAS) of BIP (n=46,918), SCZ (n=105,318), and ASD (n=10,610). To quantify the enrichment of SNP-heritability within each module, we define annotations that mark SNPs within a window around gene bodies as 1 and 0 otherwise, and use stratified linkage disequilibrium score regression to examine whether SNPs inside each module have larger effects than expected by chance. A total of 31 isoform and 16 gene (SCZ) and 16 isoform and 4 gene (BIP) modules were significantly enriched; no modules were significantly enriched in ASD (FDR < 0.05). [/av_toggle] [/av_toggle_container]