Assistant Professor of Bioengineering, University of Pennsylvania “Genome folding, unfolding, and refolding in the mammalian brain” Hosted by Hilary Coller

TITLE: "Defining chromatin accessibility and molecular dysregulation in Down Syndrome." ABSTRACT: Despite accumulating almost two centuries of medical information, the exact mechanisms underlying Down Syndrome (DS) developmental pathology remain unknown. DS is caused by trisomy of chromosome21 (T21), but without pinpointing the way in which T21 confers molecular dysfunctions and subsequently impairs neurodevelopment, it has been difficult to devise medical interventions that will reduce cognitive deficits.  In order to identify these mechanisms in DS and deconvolute the inherent complexity of the…

Associate Professor and Vice Chair of Academic Personnel, UCLA Institute for Society and Genetics “Citizen Scientific Racism: White Nationalist Appropriations of Genetic Research” Hosted by Christina Palmer  

Associate Dean for the Humanities, University of Michigan-Ann Arbor “TBD: History of genetic counseling” Hosted by Christina Palmer

TITLE: "A simple, two-step, multivalent binding model predicts IL-2 mutein cell signaling profiles." ABSTRACT: The common γ-chain cytokines are promising immune therapies, but have been limited in their efficacy due to their induction of non-specific immune activation. Here, we visualized immune cell response to both mono- and multivalent γ-chain muteins using a structured dimensionality reduction scheme. We then used a simple multivalent binding model to predict cell type-specific signaling with high accuracy. Finally, we use this model to generate guidelines for…

Associate director, Gerstner Center for Cancer Diagnostics, Broad Institute “Ultrasensitive detection of minimal residual disease” Hosted by Jasmine Zhou

TITLE: "Genome-wide survey of mutations influencing protein abundances in yeast" ABSTRACT: Our understanding of how protein-level regulation is encoded in the genome and how protein abundances are affected by DNA sequence variation remains sparse. I will discuss our genetic screen based on large-scale pooled base editing that allows us to capture the effects of thousands of mutations on the abundance of individual proteins in yeast. We applied this screen to 11 proteins and gained new insights into the components, scale…

TITLE: "Unbiased analysis of single cell RNA sequencing data reveals previously uncharacterized heterogeneity in small cell lung cancer cell lines." ABSTRACT: Small Cell Lung Cancer (SCLC) accounts for approximately 13% of all new lung cancer diagnoses. SCLC exhibits propensity for early metastasis, rapid cell division, high levels of replication stress, the ability to cope with certain oxidative and metabolic stresses, and evasion of apoptosis and the effector cells of the immune system. Together, these factors contribute to an exceedingly poor…