TITLE: “Model driven design and analysis of functional screens”
ABSTRACT: A little over a decade ago biomedicine was revolutionized by a conceptually simple insight: DNA sequencers could be used as molecular counting machines to measure a multitude of molecules beyond DNA. Through the years, sequencing has continued to become cheaper and more efficient (faster than Moore’s Law) and thousands of clever assays have been developed. This development has led to thousands of experiments done regularly with new data modalities arising continuously. However, this development has also led to a number of interesting computational problems: how does one design an experiment such that reasonable power is achieved? What can actually be measured? And finally, how does one even perform an analysis on such data once it has arrived?
