Workshop Description
Mergeomics is a computational tool designed to elucidate the underlying pathways, networks, and key regulators of complex diseases by integrating multi-omics data (genomics, transcriptomics, epigenomics, proteomics, etc). With use of integrative omics concepts and network modeling methods, this tool can uncover disease-associated gene sets and biological pathways across omics layers and can identify key drivers within gene regulatory networks or protein-protein interaction networks. In this workshop, we will first discuss the background, omics integration concepts, and capabilities of Mergeomics as well as the key analytical functions and various inputs that are commonly used. Next, we will demonstrate how this web tool can be used to analyze a complex disease by walking participants through each step within the Mergeomics web server and explain how to interpret the results.
Workshop Topics
Day 1
Day 1
- Learn the basics of the Mergeomics tool
- Review compatible omics data types and inputs
- Discuss previous research that has utilized Mergeomics
Day 2
Day 2
- Walk through Mergeomics pipeline on web server
- Demonstrate functionalities of data upload and job submission
- Discuss result files and interpretation
Day 3
Day 3
- Review steps of Mergeomics pipeline and general concepts
- Discuss common user errors
- Explain alternatives ways to use Mergeomics besides the web server and related tools
Technical Requirements
- Workshop attendees must bring a laptop that has the latest version of Safari, Google Chrome, or Firefox. Alternatively, the QCBio Collaboratory has laptops available for use during workshops.
- The Hoffman2 Cluster is not needed for this workshop
Instructor
Dr. Montgomery Blencowe is an Assistant Project Scientist working in Dr. Xia Yang’s lab in the Department of Integrative Biology and Physiology. He completed his undergraduate degree in Biomedical Science from King’s College London and then completed both his masters (Physiology) and PhD (MCIP) at UCLA focusing on integrative genomics and systems biology. His research is mainly focused on cardiometabolic diseases such as diabetes, cardiovascular disease, and fatty liver disease. Email: montyblencowe@g.ucla.edu
Cameron Gill is a Masters student in Dr. Xia Yang’s lab in the Department of Integrative Biology and Physiology. He is primarily interested in neurodevelopmental diseases and psychiatric conditions, and his current research is on autism spectrum disorder (ASD). His thesis focuses on understanding ASD-associated tissues, gene networks, and biological pathways using a systems biology, computational-based approach. Cameron received a B.S. in Physiological Sciences from UCLA in 2022, where he began his research journey under Dr. Sharmila Venugopal. Cameron’s hobbies include painting, video games, and creative writing. Email: cgill22@g.ucla.edu
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Workshop Details
Prerequisites: None
Length: 3 days, 3 hrs per day
Level: Introductory
Location: Boyer 529
Seats Available: 28
Spring 2024 Dates
May 7, 8, and 9
9:00 AM – 12:00 PM
REGISTRATION IS OPEN!