Workshop Description (Intermediate Course)

Molecular biology has taught us a great deal about what is happening inside a cell, that is that pathways can get very complicated and life is not just independent pathways but networks. Fortunately, we can use computational tools to understand dynamics of complex networks. This workshop introduces the basic concepts of modeling cell signaling pathways. In this workshop we will describe signaling pathways and network motifs using mathematical equations and will be using MATLAB to solve and plot dynamical solutions. This workshop will cover zero-, first-, and second- order chemical reaction networks and their differential equations, including how to solve them. We will explore simple signaling pathways like the MAP Kinase cascade and other simplified cascades. Finally, this workshop will go over network motifs as they relate to signaling such as positive and negative feedback, double positive and negative feedback, and feedforward loops. This workshop will include many hands-on activities with MATLAB.

Workshop Materials




Technical Requirements

Participants will need access to MATLAB –


Dr. Leo Lagunes is a postdoc in Dr. Eric Deeds’ lab where she studies proteasome assembly using both mathematical modeling and experimental techniques. Dr. Lagunes’ current research interests include understanding how proteins and protein complexes function and are assembled. Before coming to UCLA, Dr. Lagunes received a Bachelor’s degree in Applied Mathematics from CSU Fullerton and then finished her PhD in Biological Sciences from UC Irvine where she studied different mechanisms of signal transduction regulation such as scaffolding and multiple post-translational modifications.



Workshop Details

Prerequisites: Introduction to MATLAB or familiarity with MATLAB.
Length: 3 days, 3 hrs per day
Level: Intermediate
Location: Boyer 529
Seats Available: 28

Winter 2022 Dates

Feb. 8, 9 and 10
9:00 AM – 12:00 PM