2018 Bruins-In-Genomics Summer Undergraduate Research Program
2018 B.I.G. Summer Alumni Updates
- September 2018: Congratulations to our 2018 alumni who have been selected by the Annual Biomedical Research Conference for Minority Students (ABRCMS) to present their research from B.I.G. Summer. Ruth Adewale (Howard University ’19), mentored by Dr. Valerie Arboleda, and Janae Lyttle (Spelman College ’19), mentored by Dr. Luisa Iruela-Arispe, will present results from their summer research projects at ABRCMS 2018 in Indianapolis, Indiana.
2018 B.I.G. Summer Best Poster Award Winners
2018 B.I.G. Summer Participants
| Lab PIs | Mentors | Students |
|---|---|---|
| VALERIE ARBOLEDA | Maria Palafox | Amy Freiberg, Univ. of Central Florida |
| Ruth Adewale, Howard University | ||
| JASON ERNST | Adriana Sperlea | Brooke Felsheim, Washington University |
| Jennifer Chien, Wellesley College | ||
| ELEAZAR ESKIN | Robert Brown | Jinjing Zhou, UCLA |
| Sarah Faller, Duke University | ||
| Serghei Mangul | Caitlin Loeffler, UCLA | |
| Emily Wesel, Westlake-Harvard High School | ||
| Jacqueline Castellanos, Santa Monica College | ||
| Keith Mitchell, UCLA | ||
| Ram Ayyala, UCLA | ||
| Varuni Sarwal, Indian Institute of Technology | ||
| ALEXANDER HOFFMANN | Quen Cheng | Kensei Kishimoto, UCLA |
| Diane Lefaudeux | Nick Miller, Cornell University, Ithaca | |
| Simon Mitchell | Amy Tam, UCLA | |
| LUISA IRUELA-ARISPE | Milagros Romay | Janae Lyttle, Spelman College |
| Lyndon Rolle, Fisk University | ||
| HUIYING LI | Baochen Shi | Dana Franklin, Fisk University |
| Nnamdi Osakwe, North Carolina Central Univ. | ||
| STANLEY NELSON | Hane Lee | Kayla Schimke, UC Santa Cruz |
| Samuel Nkrumah, Fisk University | ||
| BENNETT NOVITCH | Ranmal Samarasinghe | Brandon Nanfito, UCLA |
| PÄIVI PAJUKANTA | Marcus Alvarez | Grant Schulte, UCLA |
| JEANETTE PAPP | Benjamin Chu | Gordon Mosher, UC Riverside |
| Marcel Nwaukwa, Univ. of Arkansas at Pine Bluff | ||
| BOGDAN PASANIUC | Kathryn Burch | Angela Wei, Univ. of Kentucky |
| Malika Kumar Freund | Daniela Perry, Cornell University | |
| MATTEO PELLEGRINI | Colin Farrell | Huiling Huang, UCLA |
| Simran Rajpal, UCLA | ||
| SRIRAM SANKARARAMAN | Robert Brown | Boyang Fu, Rutgers University |
| Jingxian (Clara) Liu, Cornell University | ||
| Arun Durvasula | Elliot Kang, Brown University | |
| Mario Paciuc, Rice University | ||
| Ariel Wu | Anna Yaschenko, Univ. of Maryland, Baltimore Co. | |
| Mohammadreza Hajy Heydary, CSU Fullerton | ||
| JAE HOON SUL | Brandon Jew | Sabrina Iddir, Univ. of Chicago |
| Huajun Zhou | Jiangyuan (Jerome) Luo, UCLA | |
| GRACE XIAO | Kikuye Koyano | Elaine Huang, Lafayette College |
| Michele Ramos Correa, CSU Northridge | ||
| JASMINE ZHOU | Shuo Li | Emily Kobayashi, UC Santa Cruz |
| Jacquelyn Roger, UC Santa Cruz |
2018 B.I.G. Summer Poster Abstracts
ANGELA WEI1, Kathryn Burch2, Claudia Giambartolomei3, Michael Gandal4, Bogdan Pasaniuc3,5,6
1 BIG Summer Program, Institute for Quantitative and Computational Biosciences,
2 Bioinformatics Interdepartmental Program,
3 Department of Pathology and Laboratory Medicine, David Geffen School of Medicine,
4 Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine,
5 Department of Human Genetics, David Geffen School of Medicine,
6 Department of Biomathematics, David Geffen School of Medicine, UCLA
Gene co-expression networks, or modules, are groups of genes that share similar expression patterns. Integrating gene modules with large-scale genetic data can help uncover mechanisms underlying complex diseases, such as psychiatric disorders. Here, we integrate 34 gene and 56 isoform modules obtained from cerebral cortex samples (n=1,322) of patients with autism (ASD), schizophrenia (SCZ), and bipolar disorder (BIP) with genome-wide association studies (GWAS) of BIP (n=46,918), SCZ (n=105,318), and ASD (n=10,610). To quantify the enrichment of SNP-heritability within each module, we define annotations that mark SNPs within a window around gene bodies as 1 and 0 otherwise, and use stratified linkage disequilibrium score regression to examine whether SNPs inside each module have larger effects than expected by chance. A total of 31 isoform and 16 gene (SCZ) and 16 isoform and 4 gene (BIP) modules were significantly enriched; no modules were significantly enriched in ASD (FDR < 0.05). [/av_toggle] [/av_toggle_container]
