TITLE: “Integrative systems analysis, applications, and challenges of single cell multiomics.”
ABSTRACT: Recent advances in single cell multiomics technologies such as single cell RNA-seq, single cell ATAC-seq, and spatial transcriptomics have brought enormous opportunities that enable our understanding of the molecular underpinnings of pathophysiology at a single cell resolution. However, integrative analysis across single cell multiomics domains and further incorporation of genetics information have proven challenging. I will introduce our recent efforts in single cell multiomics integration, network modeling, and eQTL analysis, present computational tools to carry out these analyses, and showcase application examples in studies of traumatic brain injury, Alzheimer’s disease, and genetic control of cell-type specific hypothalamic cell types to regulate energy homeostasis. I will also highlight the challenges and future directions of integrative systems analysis of single cell multiomics data.
