TITLE: “A pan-cancer landscape analysis of molecular and functional genomics in tumor proliferation.”
ABSTRACT: Rapid proliferation is a central hallmark of cancer and is associated with poor prognosis in most cancer types. My overall goal is to understand the mechanisms by which specific driver mutations and mutational signatures influence rates of tumor proliferation within and between cancer types and subtypes. I will do so by integrating model-system and patient data, providing both descriptive and mechanistic insights into the origins, consequences and targetability of unregulated proliferation in cancer.
