TITLE: “A simple, two-step, multivalent binding model predicts IL-2 mutein cell signaling profiles.”
ABSTRACT: The common γ-chain cytokines are promising immune therapies, but have been limited in their efficacy due to their induction of non-specific immune activation. Here, we visualized immune cell response to both mono- and multivalent γ-chain muteins using a structured dimensionality reduction scheme. We then used a simple multivalent binding model to predict cell type-specific signaling with high accuracy. Finally, we use this model to generate guidelines for engineering more effective γ-chain therapeutics.
