TITLE: “Walking the line between progress and paternalism in genetic counseling.” Hosted by Christina Palmer.
TITLE: "Multimodal Single-Cell Epigenomic Sequencing of the Developing Human Cerebral Cortex." ABSTRACT: Single cell epigenomic technologies allow the measurement of unique molecular signatures within cells, however cell type complexity remains highly enigmatic. Emerging methods have enabled multiple modalities of epigenomic sequencing to be gathered from the same cell. Single-nucleus methyl-3C sequencing (sn-m3C-seq) delivers the capacity to […]
TITLE: "moPepGen: a fast custom database generator from multi-omics data for proteogenomics." ABSTRACT: Cancers are driven by genomic variants such as SNV (single nucleotide variants) and INDEL, often accompanied by many transcriptional variants. Modern mass spectrometry based proteomics is able to identify and quantify peptides and proteins comprehensively, however the variant-harboring peptides that are absent […]
TITLE: "Automated genetic analysis" Hosted by Nandita Garud.
TITLE: "Genomics for precision public health in Colombia" Hosted by Juan De La Hoz.
https://socalsysbio.qcb.ucla.edu
Phylogenetics – the reconstruction of the evolutionary history of a the variety of species known to us, is among the most fundamental and traditional tasks in Biology. With the dramatic developments in molecuar biology and the exponential growth in annotated genetic sequences, novel directions and goals have been developed in this seemingly stagnant field. Phylogenetic […]
TITLE: "G-Flux: a metabolic flux and free energy analysis software for interpreting 13C, 2H, 18O, and 15N isotope tracing data." ABSTRACT: Metabolic fluxes offer insights into pathway utilization, kinetics, and thermodynamics. Stable isotope tracing and metabolic footprinting are widely used for inferring metabolic fluxes. However, quantitative flux measurement across broad metabolism remains challenging due to […]
TITLE: "PCA outperforms popular hidden variable inference methods for QTL mapping." ABSTRACT: Estimating and accounting for hidden variables is widely practiced as an important step in quantitative trait locus (QTL) analysis for improving the power of QTL identification. However, few benchmark studies have been performed to evaluate the efficacy of the various methods developed for […]
TITLE: "Stochastic Model and Optimization of SELEX." ABSTRACT: Systematic Evolution of Ligands by EXponential enrichment (SELEX) is a process to select the best aptamer sequence in a huge aptamer library that binds a specified target molecule with the highest affinity. There has been a deterministic model of SELEX, and we develop a fully discrete stochastic […]
