TITLE: "human microbiome variation across ethnicity and race” Hosted by Nandita Garud for Genetics & Genomics

TITLE: "Algorithms or experiments? How to improve transcriptome analysis” Hosted Jingyi Jessica Li for Bioinformatics

TITLE: "Quantification of Absolute Metabolite Concentrations in T cells by Shotgun Metabolomics." ABSTRACT: Quantitative understanding of immunometabolism underlies improving immune functions and developing successful immunotherapies. Kinetic and thermodynamic laws rely on absolute, not relative, metabolite concentrations to map metabolism. However, until now, comprehensive absolute metabolite quantification has been inaccessible due to the need for iterative analytical […]

TITLE: "Defining molecular dysregulation in Down Syndrome neocortex and neural progenitor cells." ABSTRACT: Down syndrome (DS) is the most common form of genetic, intellectual disability, which occurs 1 in 700 newborns and presents in patients as cognitive deficits, particularly diminished in learning, memory, and language development.1,2,3 DS symptoms result from impaired cortical development, which is […]

TITLE: "TBD" Hosted by William Hsu for Medical Informatics

TITLE: "Splicing-specific transcriptome-wide association uncovers novel genetic mechanisms for Schizophrenia." ABSTRACT: Recent studies have highlighted the essential role of RNA splicing, a key mechanism of alternative RNA processing, in establishing connections between genetic variations and disease. Genetic loci influencing RNA splicing variations show considerable influence on complex traits, possibly surpassing those affecting total gene expression. Dysregulated RNA […]

TITLE: "Modeling the heterogenous NFκB dynamics of single immune cells." ABSTRACT: Macrophages function as immune sentinel cells, initiating appropriate and specialized immune responses to a great variety of pathogens.  The transcription factor NFκB controls macrophage gene expression responses, and its temporal dynamics enable stimulus-specificity of these responses.  Using a fluorescent reporter mouse our laboratory recently […]

TITLE: "The new culture of preprint peer-review"