The goal of the workshop is to enable the participants to submit and rationally evaluate results of the AlphaFold protein structure predictions. The class will cover the basic principles of the structural biology of proteins, protein structure visualization (in pymol) and protein structure prediction. The participants will have opportunity to generate AlphaFold predictions for a […]
Fueled by technological innovations, online databases and algorithmic developments, biomedical research is rapidly becoming a data science. In this webinar, three of the most innovative UCLA faculty will share their perspectives on how biological big data are enabling their research. We will hear about robotic instrumentation that generate big data about drugs and genes, how diverse […]
This workshop will introduce the basic principles of DNA methylation and briefly describe available methods for DNA methylation assessment, focusing on bisulfite sequencing (BS-Seq). We will cover the principles of BSseq preprocessing, alignment and methylation calling, differential methylation analysis, annotation and visualization. Attendees will have the opportunity to work on real DNA methylation data provided […]
Spatial transcriptomics is an emerging field that bridges molecular biology and anatomy. Over the last decade, a battery of assays have been developed that profile gene expression in-situ, i.e, measuring the abundances of mRNA molecules in cells and tissues while retaining information about their spatial locations. This workshop will introduce the basic concepts, major techniques, […]
TITLE: "Spatial Single-Cell Mapping of Transcriptional Differences Across Genetic Backgrounds in Mouse Brains"
TITLE: "Chromosome-scale drift under stabilizing selection, with evolutionary implications"
Mergeomics is a computational tool designed to elucidate the underlying pathways, networks, and key regulators of complex diseases by integrating multi-omics data (genomics, transcriptomics, epigenomics, proteomics, etc). With use of integrative omics concepts and network modeling methods, this tool can uncover disease-associated gene sets and biological pathways across omics layers and can identify key drivers […]
RNA-seq I aims to provide an introduction and the basics tools to process raw RNA-seq data on a cluster machine (Hoffman2). The workshop can serve also as a starting point to develop a gene expression project. This workshop is divided in three days that will cover major steps of processing RNA-seq. To facilitate learning, the […]
