TITLE: "Liquid Biopsies for Precision Oncology." ABSTRACT: Liquid biopsies are new diagnostic approaches to profile molecular features of solid tumors by blood, saliva, urine, and other body fluids. Such approaches offer non-invasive options in early cancer detection, tumor sampling, continuous monitoring, and designing personalized therapeutic options. Therefore, liquid biopsies have the potential to transform the […]

TITLE: "Supervised capacity preserving mapping: a clustering guided visualization method for scRNA-seq data." ABSTRACT: Recently, various computational methods have been developed to analyze the scRNAseq data, such as clustering and visualization. However, current visualization methods, including t-SNE and UMAP, are challenged by the limited accuracy of rendering the geometric relationship of populations with distinct functional […]

TITLE: "Proteogenomic characterization of the molecular determinants of prostate cancer radioresistance." ABSTRACT: Prostate Cancer (PC), the second most common cause of cancer death in men, is frequently treated using radiotherapy with curative intent. Despite its effectiveness, radiotherapy often results in aggressive PC relapse characterized by radioresistance. The diversity in therapeutic response to radiotherapy, and the molecular […]

TITLE: "Heterogeneity in cell states: Is it important whether cell states are heritable or change rapidly?" ABSTRACT: Cells of the same cell type show molecular and phenotypic heterogeneity. Is the particular cell state of a given cell heritable from one generation to the next?  Previous work in liver cancer cells indicates that the molecular network […]

TITLE: "A lack of distinct cellular identities in scRNA-seq data: revisiting Waddington’s landscape". ABSTRACT: Single-cell RNA sequencing is revolutionizing our understanding of development, differentiation and disease. Analysis of this data is often challenging, however, and tasks like clustering cells to uncover distinct cellular identities sometimes yields results that fail to align with existing biological knowledge. We analyzed publicly available data where […]