TITLE: “A pan-cancer multi-omic analysis of tumor proliferation.”
ABSTRACT: The underlying mechanisms of dysregulated cellular proliferation in cancer remain unclear; however, it is hypothesized that specific mutations, mutational signatures, evolutionary trajectories and other global (epi)genomic features may be linked to differing rates of proliferation. In this presentation, I will showcase a landscape analysis of cellular proliferation across primary cancers and cell lines using genome, transcriptome and proteome data from 11,597 primary tumors and 1,804 cell lines across six major consortia. The approach is to develop computational pipelines that will take in next-generation sequenced, multi-omic datasets from an expanding source of consortia, apply rigorous statistical methods to test multiple hypotheses on the global, functional and pharmacogenomics of tumor proliferation and output detailed integration analyses on the underlying genomics of tumor proliferation. By evaluating proliferation at these molecular levels, key insights will be yielded including expansive new resources on the variation of proliferation rate across and within cancer types.
For lunch at 12:30pm with the speaker, please RSVP at qcboffice@lifesci.ucla.edu
