TITLE: "ClusterDE: a post-clustering differentially expressed (DE) gene identification method robust to false-positive inflation caused by double-dipping" ABSTRACT: In typical single-cell RNA-seq data analysis, first, a clustering algorithm is applied to cluster cells; then, a statistical method is used to identify the differentially expressed (DE) genes between the cell clusters. However, this common procedure uses the same […]

TITLE: "Germline structural variants shape prostate cancer clinical and molecular evolution." ABSTRACT: Inherited genetic variation profoundly influences cancer risk and outcome. While the impact of germline single nucleotide polymorphisms has been well-studied in several cancer types, the effects of germline structural variants (gSVs) on cancer biology and clinical outcomes is largely unknown. From our cohort […]