QCBio/Bioinformatics/Human Genetics seminar: Soojin Yi, PhD, Professor, Ecology, Evolution, and Marine Biology, UC Santa Barbara
TITLE: “DNA Methylation in Brain Evolution and Neuropsychiatric Disorders.”
TITLE: “DNA Methylation in Brain Evolution and Neuropsychiatric Disorders.”
TITLE: “New perspectives to dissect global dynamics of protein interactome and gene regulation in disease.”
TITLE: "TBA"
TITLE: “Why do human germline mutation rates depend on sex and age.”
TITLE: “Stochasticity in cancer immunotherapies: identifying the T cell subset that sparks tumor eradication” ABSTRACT: We use an ex vivo model of tumor eradication to dissect the fundamental variability of clinical outcomes in cancer immunotherapies. We demonstrate that there exists an inherent stochastic variability in immune responses, based on the low abundance of hyper-responsive naïve T cells (so-called […]
TITLE: "Stochasticity in cancer immunotherapies: identifying the T cell subset that sparks tumor eradication" ABSTRACT: We use an ex vivo model of tumor eradication to dissect the fundamental variability of clinical outcomes in cancer immunotherapies. We demonstrate that there exists an inherent stochastic variability in immune responses, based on the low abundance of hyper-responsive naïve T cells (so-called Spark T cells) and feedback regulations […]
TITLE: “Pushing the boundaries of causal inference.”
TITLE: "“Cross-tissue multiomics studies reveal gutbrain interactions mediating the effect of Akkermansia muciniphila in counteracting fructose-induced obesity” ABSTRACT: The gut bacterium Akkermansia muciniphila (A. muciniphila) has been implicated in anti-obesity effects, but a systems level understanding of the molecular mechanisms is lacking. We carried out multiomics studies to investigate the molecular cascades mediating the anti-obesity effect of A. muciniphila in a fructoseinduced obesity mouse model. […]
TITLE: "Exercise and tumor genomic landscapes in 2,702 patients with cancer" ABSTRACT: Approximately two-thirds of cancer diagnoses globally are attributed to modifiable lifestyle factors such as smoking, diet and inactivity. Conversely, regular exercise is linked to decreased risk of multiple cancers. However, the underlying molecular mechanisms are not fully elucidated. Specifically, how exercise impacts tumor genomic […]
TITLE: “Automatic analysis of cryo-electron tomography using computer vision and machine learning.”