TITLE: "“Cross-tissue multiomics studies reveal gutbrain interactions mediating the effect of Akkermansia muciniphila in counteracting fructose-induced obesity” ABSTRACT: The gut bacterium Akkermansia muciniphila (A. muciniphila) has been implicated in anti-obesity effects, but a systems level understanding of the molecular mechanisms is lacking. We carried out multiomics studies to investigate the molecular cascades mediating the anti-obesity effect of A. muciniphila in a fructoseinduced obesity mouse model. […]

TITLE: “Pushing the boundaries of causal inference.”

TITLE: "Stochasticity in cancer immunotherapies: identifying the T cell subset that sparks tumor eradication" ABSTRACT: We use an ex vivo model of tumor eradication to dissect the fundamental variability of clinical outcomes in cancer immunotherapies. We demonstrate that there exists an inherent stochastic variability in immune responses, based on the low abundance of hyper-responsive naïve T cells (so-called Spark T cells) and feedback regulations […]