UCLA Health serves well over half a million patients annually, and as a result, UCLA possesses a vast database of Electronic Health Records (EHR). The stemming Discovery Data Repository (DDR) serves as an invaluable resource for researchers. This introductory workshop will cover the basics of writing queries to extract the relevant datasets for EHR-related research […]
“A lack of distinct cellular identities in scRNA-seq data: revisiting Waddington’s landscape” Single-cell RNA sequencing is revolutionizing our understanding of development, differentiation and disease. Analysis of this data is often challenging, however, and tasks like clustering cells to uncover distinct cellular identities sometimes yields results that fail to align with existing biological knowledge. We analyzed […]
“Unraveling Signaling Pathway Crosstalk Using LLMs” Living cells do not process information through isolated, linear pathways. Instead, they rely on an intricate network of signaling crosstalk to make critical fate decisions. Deciphering this hidden cellular conversation remains one of the greatest challenges in targeted oncology and regenerative medicine. Yet traditional mechanistic models struggle to capture […]
TITLE: "Evolutionary perspectives on malaria" Pathogen genomics increasingly guides public health decisions, yet organisms with complex life cycles can produce genealogies that violate assumptions of standard population genetic methods. Similarly, despite decades of population-genetic methods to infer population or adaptive histories in humans, allele frequencies are often modeled to be roughly constant on short timescales […]
"Building an Integrative View of Immunity with Data Tensors" High-throughput technologies now allow us to characterize immune responses with comprehensive scale and detail. While profiling cells across parameters like time, perturbations, and genetics yields rich data, these multidimensional datasets challenge conventional analysis. Standard workflows typically flatten data into two-dimensional matrices, sacrificing the essential context provided […]
"Insights into the evolutionary and genetic architecture of human complex traits from biobank-scale data" The quest to understand the interplay between evolution, genes and traits has been revolutionized by the collection of rich phenotypic and genetic data across millions of individuals in diverse populations. However analyses of these Biobank-scale datasets present substantial statistical and computational challenges. […]
High-throughput sequencing technology involves a number of concepts and techniques that shape a project before application-specific processes are utilized. First, this workshop introduces the more “universal” aspects of high-throughput sequence […]
This workshop will cover some more advanced topics in python including an overview of object-oriented python (this will not be an in-depth course on object-oriented programming), use of the numpy […]
This workshop will cover the basic concepts of Python programming. The course is supplemented with many hands-on exercises with emphasis given towards computational biology use cases.
Unix is a command-line-based platform that is a highly powerful and flexible tool for data management and analysis. First, this workshop introduces the basic concepts of UNIX operating system and […]
