TITLE: "Building a tooth from transcriptome to tissue morphogenesis" ABSTRACT: During craniofacial development, the oral epithelium begins as a morphologically homogeneous tissue that gives rise to locally complex structures, including the teeth, salivary glands, and taste buds. How the epithelium is initially patterned and later shaped to generate diverse organ and cell types remains largely […]

TITLE: "Single Cell Multiomics Integration to Understand Complex Diseases." ABSTRACT: Recent advances in single cell multiomics technologies such as single cell RNA-seq, single cell ATAC-seq, and spatial transcriptomics have brought enormous opportunities that enable our understanding of the molecular underpinnings of pathophysiology at a single cell or cell type resolution. However, integrative analysis across single […]

TITLE: "A lack of distinct cellular identities in scRNA-seq data: revisiting Waddington’s landscape." ABSTRACT: Single-cell RNA sequencing is revolutionizing our understanding of development, differentiation and disease. Analysis of this data is often challenging, however, and tasks like clustering cells to uncover distinct cellular identities sometimes yields results that fail to align with existing biological knowledge. We analyzed […]

TITLE: “Automatic analysis of cryo-electron tomography using computer vision and machine learning.”

TITLE: “Pushing the boundaries of causal inference.”