TITLE: “Why do human germline mutation rates depend on sex and age.”
TITLE: "TBA"
TITLE: “New perspectives to dissect global dynamics of protein interactome and gene regulation in disease.”
TITLE: “DNA Methylation in Brain Evolution and Neuropsychiatric Disorders.”
TITLE: “Part 1: "How important is evolution vs transmission of drug resistance". Part 2: "Computing skills for every biology student."
TITLE: "Electric actuation of DNA-based molecular machines.” ABSTRACT: A wide range of machine-like molecular assemblies have been generated over the past years. Most of them have been driven (or controlled) by DNA hybridization, utilization of buffer changes, or using chemical modifications such as photoswitches. A more recently explored strategy is the use of electrical fields for the manipulation of DNA devices, which enables fast […]
TITLE: "scReadSim: a single-cell RNA-seq and ATAC-seq read simulator." ABSTRACT: Rapid advances of single-cell RNA-seq and ATAC-seq technologies have propelled the development of many computational tools, benchmarking of which demands realistic simulators. However, few simulators can generate sequencing reads, and none of the existing read simulators aim to mimic real cells, hindering the benchmarking of […]
TITLE: “Integrative systems analysis, applications, and challenges of single cell multiomics.” ABSTRACT: Recent advances in single cell multiomics technologies such as single cell RNA-seq, single cell ATAC-seq, and spatial transcriptomics have brought enormous opportunities that enable our understanding of the molecular underpinnings of pathophysiology at a single cell resolution. However, integrative analysis across single cell […]
TITLE: "Evolutionary dynamics in the human gut microbiome from infancy through adulthood." ABSTRACT: While the ecological dynamics of the infant gut microbiome have been intensely studied, relatively little is known about the evolutionary dynamics in the infant gut microbiome. Here we analyze longitudinal fecal metagenomic data from >700 infants and their mothers over the first […]
TITLE: "Model driven design and analysis of functional screens" ABSTRACT: A little over a decade ago biomedicine was revolutionized by a conceptually simple insight: DNA sequencers could be used as molecular counting machines to measure a multitude of molecules beyond DNA. Through the years, sequencing has continued to become cheaper and more efficient (faster than […]
