TITLE: “Merging Experimental and Computational Approaches to Study Neurodegenerative Disease Dynamics” ABSTRACT: "Neurodegenerative diseases such as Alzheimer's and Parkinson's affect millions of people around the world and are a growing health concern in aging populations. A major roadblock in developing effective treatments involve the diverse etiology and progression rates, combined with a lack of clear understanding of […]

TITLE: "A quantitative view of strategies to engineer cell-selective ligand binding" ABSTRACT: Selective binding to specific target cells is a critical property of many therapies. To enhance selectivity in specific situations, a series of new strategies have been proposed in the drug development literature, including affinity, valency, multi-specificity, and other alterations to target cell binding. […]

TITLE: "Organoid Maturation by Circadian Entrainment " ABSTRACT: Stem cell-derived tissues that recap endogenous physiology are key for regenerative medicine. Yet, most methods yield products that function like fetal, not adult tissues. Organoids are typically grown in constant environments, while our tissues mature along with behavioral cycles. I show that inducing circadian rhythms in pancreatic islet organoids, […]