TITLE: "Characterizing distinct cell states based on stimulus-response dynamics." ABSTRACT: Macrophages show remarkable functional pleiotropy that is dependent on microenvironmental context. Prior studies have characterized how polarizing cytokines alter epigenetic or signaling mechanisms, but how they affect specific macrophage functions has not been characterized systematically. One hallmark function of macrophages is to mount immune-threat appropriate […]

TITLE: "Quantitative flux analysis reveals redistribution of glycolytic pathways in dynamic nutrient environments." ABSTRACT: Optimal operation of metabolic fluxes is critical for an organism to be evolutionarily competitive. Textbook glycolysis is a conserved pathway that optimally utilizes carbohydrates for growth. However, it is unclear why some organisms simultaneously possess the parallel Entner-Doudoroff (ED) pathway, which […]