TITLE: "Quantifying response-specificity to diverse immune threats from single cell transcriptomes" ABSTRACT: Innate immune sentinel cells such as macrophages upregulate over a thousand genes in the minutes to hours following an encounter with pathogen invaders or damage signals. Previous bulk transcriptomic studies suggest there is stimulus-specificity in the combinations of genes that are activated. However, bulk […]
TITLE: “Inferring positive selection in the human gut microbiome using signatures of genetic linkage.” ABSTRACT: The human gut microbiome is composed of hundreds of simultaneously evolving species that can affect human health. However, fundamental features of genetic diversity have yet to be leveraged to identify genes that contribute towards microbial adaptation. One such feature is the […]
TITLE: "Linking exposure dose to infectious disease development using mechanistic models" (using SARS-CoV-2 in a mouse model as an illustration) ABSTRACT: Disease development after exposure to a pathogen does not follow a yes/no process, but rather a spectrum of disease manifestations influenced by host, pathogen and environmental factors. In particular, exposure dose can impact incubation time, […]
